Publication Name	World Journal of Gastroenterology
Manuscript ID	15907
Country	China

Received	2014-12-16 11:41
Peer-Review Started	2014-12-16 15:05
To Make the First Decision	2015-01-08 16:54
Return for Revision	2015-01-13 08:45
Revised	2015-01-15 15:15
Second Decision	2015-02-11 23:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-13 11:06
Articles in Press	2015-02-13 11:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-04-02 15:48
Typeset the Manuscript	2015-05-08 19:00
Publish the Manuscript Online	2015-05-20 17:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Basic Study
Article Title	miR-451 inhibits proliferation of esophageal carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Qiao Zang, Xuan Yang, Tao Wang, Yuan-Yuan Wang, Yu-Wen Du, Xiao-Nan Chen, Min Li and Guo-Qiang Zhao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81301726
Corresponding Author	Guo-Qiang Zhao, PhD, College of Basic Medical Sciences, Zhengzhou University, 40 Daxue North Road, 450001 Zhengzhou, Henan Province, China. zhaogq@zzu.edu.cn
Key Words	Esophageal squamous cell carcinoma; miR-451; CDKN2D; MAP3K1; Proliferation
Core Tip	Recently miR-451 has been reported to be tumor suppressor in human cancer cells. In the previous studies we have reported that miR-451expression in esophageal squamous cell carcinoma (ESCC) tissues was significantly reduced, and that upregulated expression of miR-451 induced apoptosis and suppressed cell proliferation, invasion and metastasis in the esophageal carcinoma. However, the underlying molecular mechanisms remain unclear. In this study, we supposed and showed that CDKN2D and MAP3K1 were the targets of miR-451by the bioinformatics algorithms (TargetScan and miRBase), moreover, CDKN2D and MAP3K1 contributed to ESCC malignancy.
Publish Date	2015-05-20 17:01
Citation	Zang WQ, Yang X, Wang T, Wang YY, Du YW, Chen XN, Li M, Zhao GQ. MiR-451 inhibits proliferation of esophageal carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1. World J Gastroenterol 2015; 21(19): 5867-5876
URL	http://www.wjgnet.com/1007-9327/full/v21/i19/5867.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i19.5867

Full Article (PDF)	WJG-21-5867.pdf
Full Article (Word)	WJG-21-5867.doc
Manuscript File	15907-Review.docx
Answering Reviewers	15907-Answering reviewers.pdf
Audio Core Tip	15907-Audio core tip.mp3
Biostatistics Review Certificate	15907-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	15907-Conflict-of-interest statement.pdf
Copyright License Agreement	15907-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	15907-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	15907-Institutional review board statement.pdf
Peer-review Report	15907-Peer-review(s).pdf
Scientific Misconduct Check	15907-Scientific misconduct check.pdf
Scientific Editor Work List	15907-Scientific editor work list.pdf