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7/8/2015 12:00:00 PM | Browse: 499 | Download: 684
Publication Name World Journal of Gastroenterology
Manuscript ID 16059
Country of Manuscript Source United Kingdom
Received
2014-12-24 09:31
Peer-Review Started
2014-12-25 09:46
To Make the First Decision
2015-03-10 20:18
Return for Revision
2015-03-13 09:01
Revised
Second Decision
2015-05-13 07:30
Accepted by Journal Editor-in-Chief
2015-05-13 10:01
Accepted by Company Editor-in-Chief
2015-05-27 19:38
Articles in Press
2015-05-27 19:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-25 10:18
Publish the Manuscript Online
2015-07-08 12:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Prospective Study
Article Title Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome
Manuscript Source Invited Manuscript
All Author List Konstantinos Kargiotis, Vasilios G Athyros, Olga Giouleme, Niki Katsiki, Evangelia Katsiki, Panagiotis Anagnostis, Chrysoula Boutari, Michael Doumas, Asterios Karagiannis and Dimitri P Mikhailidis
Funding Agency and Grant Number
Corresponding author Dimitri P Mikhailidis, MD, FFPM, FRCP, FRCPath Academic Head, Department of Clinical Biochemistry (Vascular Disease Prevention Clinic), Royal Free Hospital Campus, University College London Medical School, University College London, Pond Street, NW3 2QG London, United Kingdom. mikhailidis@aol.com
Keywords Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Metabolic syndrome; Dyslipidaemia; Rosuvastatin; Fasting blood glucose; Serum uric acid
Core Tip We treated 20 patients with metabolic syndrome (MetS) and biopsy proven non-alcoholic steatohepatitis (NASH) with rosuvastatin monotherapy for one year. Repeat liver biopsy and ultrasonography showed complete resolution of NASH in 19 patients, and normalization of liver enzymes, lipid profile and blood glucose; no patient had MetS at the end of the study. These findings suggest that rosuvastatin monotherapy could ameliorate biopsy proven NASH and resolve MetS within 12 mo. These effects and the reduction of fasting plasma glucose and serum uric acid levels, if confirmed by larger studies, may reduce the risk of vascular and liver morbidity and mortality in NASH patients.
Publish Date 2015-07-08 12:01
Citation Kargiotis K, Athyros VG, Giouleme O, Katsiki N, Katsiki E, Anagnostis P, Boutari C, Doumas M, Karagiannis A, Mikhailidis DP. Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome. World J Gastroenterol 2015; 21(25): 7860-7868
Url http://www.wjgnet.com/1007-9327/full/v21/i25/7860.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i25.7860
Full Article (PDF) WJG-21-7860.pdf
Full Article (Word) WJG-21-7860.doc
Manuscript File 16059-Review.docx
Answering Reviewers 16059-Answering reviewers.pdf
Audio Core Tip 16059-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 16059-Conflict-of-interest statement.pdf
Copyright License Agreement 16059-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20141223163445.pdf
Institutional Review Board Approval Form or Document 16059-Institutional review board statement.pdf
Peer-review Report 16059-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16059-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16059-Scientific misconduct check.pdf
Scientific Editor Work List 16059-Scientific editor work list.pdf