Publication Name	World Journal of Hepatology
Manuscript ID	16069
Country	United States

Received	2014-12-24 10:06
Peer-Review Started	2014-12-26 10:57
To Make the First Decision	2015-01-20 13:41
Return for Revision	2015-01-23 09:22
Revised	2015-03-05 00:00
Second Decision	2015-04-01 15:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-04-14 16:10
Articles in Press	2015-04-14 16:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-14 17:39
Publish the Manuscript Online	2015-06-03 12:00

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Alpha-1 antitrypsin deficiency and the risk of hepatocellular carcinoma in end-stage liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Clara Antoury, Rocio Lopez, Nizar Zein, James K Stoller and Naim Alkhouri
Funding Agency and Grant Number
Corresponding Author	Clara Antoury, MD, Department of Internal Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, United States. antourc@ccf.org
Key Words	Hepatocellular carcinoma; Liver cirrhosis; End-stage liver disease; Hepatitis C virus; Alpha-1 antitrypsin deficiency
Core Tip	It’s been postulated that alpha-1 antitrypsin deficiency (A1ATD) and the presence of the Z allele increase the risk of hepatocellular carcinoma (HCC) above that attributable to cirrhosis alone. Our study showed that the occurrence of HCC in subjects with cirrhosis due to A1ATD was 0.88%/year. This incidence rate was considerably lower than that among patients with other causes of liver disease including hepatitis C, alcoholic liver disease and non-alcoholic liver stea-tohepatitis. This challenges the view that A1ATD confers a disproportionate risk of HCC.
Publish Date	2015-06-03 12:00
Citation	Antoury C, Lopez R, Zein N, Stoller JK, Alkhouri N. Alpha-1 antitrypsin deficiency and the risk of hepatocellular carcinoma in end-stage liver disease. World J Hepatol 2015; 7(10): 1427-1432
URL	http://www.wjgnet.com/1948-5182/full/v7/i10/1427.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i10.1427

Full Article (PDF)	WJH-7-1427.pdf
Full Article (Word)	WJH-7-1427.doc
Manuscript File	16069-Review.docx
Answering Reviewers	16069-Answering reviewers.pdf
Audio Core Tip	16069-Audio core tip.wma
Biostatistics Review Certificate	16069-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	16069-Conflict-of-interest statement.pdf
Copyright License Agreement	16069-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	16069-Institutional review board statement.pdf
Peer-review Report	16069-Peer-review(s).pdf
Scientific Misconduct Check	16069-Scientific misconduct check.pdf
Scientific Editor Work List	16069-Scientific editor work list.pdf