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6/20/2015 5:38:00 PM | Browse: 462 | Download: 685
Publication Name World Journal of Gastroenterology
Manuscript ID 16142
Country of Manuscript Source China
Received
2014-12-29 10:19
Peer-Review Started
2014-12-29 19:05
To Make the First Decision
2015-01-22 16:36
Return for Revision
2015-02-03 07:48
Revised
2015-02-20 19:12
Second Decision
2015-04-07 17:08
Accepted by Journal Editor-in-Chief
2015-04-07 17:28
Accepted by Company Editor-in-Chief
2015-04-09 17:01
Articles in Press
2015-04-09 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-05-04 09:53
Typeset the Manuscript
2015-06-04 15:16
Publish the Manuscript Online
2015-06-20 17:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Abundance and significance of neuroligin-1 and glutamate in Hirschsprung’s disease
Manuscript Source Unsolicited Manuscript
All Author List Jian Wang, Hao Du, Ya-Ru Mou, Jian-Yi Niu, Wen-Tong Zhang, Hong-Chao Yang and Ai-Wu Li
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81270720
National Natural Science Foundation of China 81471487
Corresponding author Ai-Wu Li, PhD, Department of Pediatric Surgery, QiluHospital, Shandong University, 107 Wenhuaxi Road, Jinan 250012, Shandong Province, China. zisetianxie@163.com
Keywords Neuroligin-1; Hirschsprung’s disease; Glutamate; Ganglion cells; Pathogenesis
Core Tip Based on our results derived from a large set clinical samples and various experimental methods, neuroligin-1 and glutamate (Glu) were first shown to be co-expressed in ganglion cells; thus neuroligin-1 and Glu may serve as new markers of this cell type, especially for excitatory synapses in the enteric nervous system. Moreover, the decreased abundance of neuroligin-1 and Glu in aganglionic segments may correlate with excessive intestinale contraction because of abnormal excitatory signaling that may ultimately result in Hirschsprung’s disease (HSCR). The serum Glu concentration may serve as a valuable adjunct measure for establishing a diagnosis and classification of HSCR.
Publish Date 2015-06-20 17:38
Citation Wang J, Du H, Mou YR, Niu JY, Zhang WT, Yang HC, Li AW. Abundance and significance of neuroligin-1 and glutamate in Hirschsprung’s disease. World J Gastroenterol 2015; 21(23): 7172-7180
Url http://www.wjgnet.com/1007-9327/full/v21/i23/7172.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i23.7172
Full Article (PDF) WJG-21-7172.pdf
Full Article (Word) WJG-21-7172.doc
Manuscript File 16142-Review.docx
Answering Reviewers 16142-Answering reviewers.pdf
Audio Core Tip 16142-Audio core tip.mp3
Biostatistics Review Certificate 16142-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 16142-Conflict-of-interest statement.pdf
Copyright License Agreement 16142-Copyright assignment.pdf
Data Sharing Statement 16142-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 16142-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 16142-Language certificate.pdf
Peer-review Report 16142-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16142-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16142-Scientific misconduct check.pdf
Scientific Editor Work List 16142-Scientific editor work list.pdf