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Articles Published Processes
6/20/2015 5:38:00 PM | Browse: 1227 | Download: 2343
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Received |
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2014-12-29 10:19 |
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Peer-Review Started |
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2014-12-29 19:05 |
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To Make the First Decision |
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2015-01-22 16:36 |
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Return for Revision |
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2015-02-03 07:48 |
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Revised |
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2015-02-20 19:12 |
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Second Decision |
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2015-04-07 17:08 |
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Accepted by Journal Editor-in-Chief |
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2015-04-07 17:28 |
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Accepted by Executive Editor-in-Chief |
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2015-04-09 17:01 |
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Articles in Press |
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2015-04-09 17:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-05-04 09:53 |
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Typeset the Manuscript |
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2015-06-04 15:16 |
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Publish the Manuscript Online |
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2015-06-20 17:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Abundance and significance of neuroligin-1 and glutamate in Hirschsprung’s disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jian Wang, Hao Du, Ya-Ru Mou, Jian-Yi Niu, Wen-Tong Zhang, Hong-Chao Yang and Ai-Wu Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81270720 |
| National Natural Science Foundation of China |
81471487 |
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| Corresponding Author |
Ai-Wu Li, PhD, Department of Pediatric Surgery, QiluHospital, Shandong University, 107 Wenhuaxi Road, Jinan 250012, Shandong Province, China. zisetianxie@163.com |
| Key Words |
Neuroligin-1; Hirschsprung’s disease; Glutamate; Ganglion cells; Pathogenesis |
| Core Tip |
Based on our results derived from a large set clinical samples and various experimental methods, neuroligin-1 and glutamate (Glu) were first shown to be co-expressed in ganglion cells; thus neuroligin-1 and Glu may serve as new markers of this cell type, especially for excitatory synapses in the enteric nervous system. Moreover, the decreased abundance of neuroligin-1 and Glu in aganglionic segments may correlate with excessive intestinale contraction because of abnormal excitatory signaling that may ultimately result in Hirschsprung’s disease (HSCR). The serum Glu concentration may serve as a valuable adjunct measure for establishing a diagnosis and classification of HSCR. |
| Publish Date |
2015-06-20 17:38 |
| Citation |
Wang J, Du H, Mou YR, Niu JY, Zhang WT, Yang HC, Li AW. Abundance and significance of neuroligin-1 and glutamate in Hirschsprung’s disease. World J Gastroenterol 2015; 21(23): 7172-7180 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i23/7172.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i23.7172 |
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