Publication Name	World Journal of Gastroenterology
Manuscript ID	16185
Country	South Korea

Received	2015-01-01 17:37
Peer-Review Started	2015-01-02 23:53
To Make the First Decision	2015-01-22 16:35
Return for Revision	2015-02-03 07:52
Revised	2015-03-02 22:49
Second Decision	2015-04-17 08:50
Accepted by Journal Editor-in-Chief	2015-04-17 13:45
Accepted by Executive Editor-in-Chief	2015-04-28 18:21
Articles in Press	2015-04-28 18:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-16 11:56
Publish the Manuscript Online	2015-06-29 16:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Increased liver markers are associated with higher risk of type 2 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Sun-Hye Ko, Myong Ki Baeg, Kyung-Do Han, Seung-Hyun Ko and Yu-Bae Ahn
Funding Agency and Grant Number
Corresponding Author	Yu-Bae Ahn, MD, PhD, Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-Gu, Seoul 137-701, South Korea. yoonk@catholic.ac.kr
Key Words	Type 2 diabetes mellitus; Liver markers; Impaired fasting glucose; Gamma-glutamyl transferase; Aspartate aminotransferase; Alanine aminotransferase
Core Tip	We investigated the association between liver markers and the risk of type 2 diabetes (T2DM) and impaired fasting glucose (IFG) in a general Korean population. Increasing quartiles of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) were positively and aspartate aminotransferase (AST)/ALT was negatively correlated with both T2DM and IFG. Analysis of the liver marker combinations showed that if any two or more markers were in the highest risk quartile, the risks of both T2DM and IFG increased significantly. Higher levels of GGT and ALT and lower AST/ALT within the physiological range are independent, additive risk factors of T2DM and IFG.
Publish Date	2015-06-29 16:33
Citation	Ko SH, Baeg MK, Han KD, Ko SH, Ahn YB. Increased liver markers are associated with higher risk of type 2 diabetes. World J Gastroenterol 2015; 21(24): 7478-7487
URL	http://www.wjgnet.com/1007-9327/full/v21/i24/7478.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i24.7478

Full Article (PDF)	WJG-21-7478.pdf
Full Article (Word)	WJG-21-7478.doc
Manuscript File	16185-Review.docx
Answering Reviewers	16185-Answering reviewers.pdf
Audio Core Tip	16185-Audio core tip.mp3
Biostatistics Review Certificate	16185-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	16185-Conflict-of-interest statement.pdf
Copyright License Agreement	16185-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	16185-Institutional review board statement.pdf
Peer-review Report	16185-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16185-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16185-Scientific misconduct check.pdf
Scientific Editor Work List	16185-Scientific editor work list.pdf