Publication Name	World Journal of Immunology
Manuscript ID	16510
Country	Spain

Received	2015-01-21 09:25
Peer-Review Started	2015-01-22 08:45
To Make the First Decision	2015-03-06 10:14
Return for Revision	2015-03-14 20:52
Revised	2015-03-27 17:24
Second Decision	2015-06-01 08:59
Accepted by Journal Editor-in-Chief	2015-06-01 09:55
Accepted by Executive Editor-in-Chief	2015-07-17 14:16
Articles in Press	2015-07-17 14:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-24 14:11
Publish the Manuscript Online	2015-08-04 10:49

ISSN	2219-2824 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Editorial
Article Title	Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasis
Manuscript Source	Invited Manuscript
All Author List	Rubén Varela-Calviño and Oscar J Cordero
Funding Agency and Grant Number
Corresponding Author	Oscar J Cordero, PhD, Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, CIBUS Building, Campus Vida, 15782 Santiago de Compostela, Spain. oscarj.cordero@usc.es
Key Words	Colorectal cancer; Metastasis; Stem cells; Immune surveillance; Dendritic cells; Prognosis; Flow cytometry; Lymphocytes; Regulatory cells
Core Tip	Metastasis relies on differentiation of some cancer stem cells in the primary tumour niche led by many micro-environmental signals. These signals include the participation of immune cell subsets such as tumour-infiltrating lymphocytes, dendritic cells and regulatory populations. Metastatic stem cells can be identified in the removed primary tumour. The study of the number and function of these immune cell populations in parallel with metastatic stem cells (MetSCs) in the primary tumour, together with follow-up data of patients, will define the usefulness of specific immune and MetSCs cell population combinations. This can be combined with defining new biomarkers as future predictors of tumour recurrences, metastases and/or mortality in colorectal cancer.
Publish Date	2015-08-04 10:49
Citation	Varela-Calviño R, Cordero OJ. Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasis. World J Immunol 2015; 5(2): 68-77
URL	http://www.wjgnet.com/2219-2824/full/v5/i2/68.htm
DOI	http://dx.doi.org/10.5411/wji.v5.i2.68

Full Article (PDF)	WJI-5-68.pdf
Full Article (Word)	WJI-5-68.doc
Manuscript File	16510-Review.docx
Answering Reviewers	16510-Answering reviewers.pdf
Audio Core Tip	16510-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16510-Conflict-of-interest statement.pdf
Copyright License Agreement	16510-Copyright assignment.pdf
Peer-review Report	16510-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16510-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16510-Scientific misconduct check.pdf
Scientific Editor Work List	16510-Scientific editor work list.pdf