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8/4/2015 10:48:00 AM | Browse: 1072 | Download: 1810
Publication Name World Journal of Immunology
Manuscript ID 16510
Country/Territory Spain
Received
2015-01-21 09:25
Peer-Review Started
2015-01-22 08:45
To Make the First Decision
2015-03-06 10:14
Return for Revision
2015-03-14 20:52
Revised
2015-03-27 17:24
Second Decision
2015-06-01 08:59
Accepted by Journal Editor-in-Chief
2015-06-01 09:55
Accepted by Company Editor-in-Chief
2015-07-17 14:16
Articles in Press
2015-07-17 14:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-07-24 14:11
Publish the Manuscript Online
2015-08-04 10:49
ISSN 2219-2824 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Editorial
Article Title Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasis
Manuscript Source Invited Manuscript
All Author List Rubén Varela-Calviño and Oscar J Cordero
Funding Agency and Grant Number
Corresponding Author Oscar J Cordero, PhD, Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, CIBUS Building, Campus Vida, 15782 Santiago de Compostela, Spain. oscarj.cordero@usc.es
Key Words Colorectal cancer; Metastasis; Stem cells; Immune surveillance; Dendritic cells; Prognosis; Flow cytometry; Lymphocytes; Regulatory cells
Core Tip Metastasis relies on differentiation of some cancer stem cells in the primary tumour niche led by many micro-environmental signals. These signals include the participation of immune cell subsets such as tumour-infiltrating lymphocytes, dendritic cells and regulatory populations. Metastatic stem cells can be identified in the removed primary tumour. The study of the number and function of these immune cell populations in parallel with metastatic stem cells (MetSCs) in the primary tumour, together with follow-up data of patients, will define the usefulness of specific immune and MetSCs cell population combinations. This can be combined with defining new biomarkers as future predictors of tumour recurrences, metastases and/or mortality in colorectal cancer.
Publish Date 2015-08-04 10:49
Citation Varela-Calviño R, Cordero OJ. Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasis. World J Immunol 2015; 5(2): 68-77
URL http://www.wjgnet.com/2219-2824/full/v5/i2/68.htm
DOI http://dx.doi.org/10.5411/wji.v5.i2.68
Full Article (PDF) WJI-5-68.pdf
Full Article (Word) WJI-5-68.doc
Manuscript File 16510-Review.docx
Answering Reviewers 16510-Answering reviewers.pdf
Audio Core Tip 16510-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 16510-Conflict-of-interest statement.pdf
Copyright License Agreement 16510-Copyright assignment.pdf
Peer-review Report 16510-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16510-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16510-Scientific misconduct check.pdf
Scientific Editor Work List 16510-Scientific editor work list.pdf