Publication Name	World Journal of Gastroenterology
Manuscript ID	1654
Country	United States

Received	2012-12-25 22:46
Peer-Review Started	2012-12-26 15:37
To Make the First Decision	2013-01-05 11:37
Return for Revision	2013-01-06 15:19
Revised	2013-02-12 18:25
Second Decision	2013-04-18 16:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-04-19 06:25
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-19 09:26
Publish the Manuscript Online	2013-07-29 11:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Case Report
Article Title	Neuroendocrine carcinoma of the extrahepatic bile duct: Case report and literature review
Manuscript Source	Invited Manuscript
All Author List	Eizaburo Sasatomi, Michael A Nalesnik and J Wallis Marsh
Funding Agency and Grant Number
Corresponding Author	Eizaburo Sasatomi, MD, PhD, Department of Pathology, University of Pittsburgh Medical Center, Montefiore University Hospital, Rm E-734, Pittsburgh, PA 15213, United States. sasatomie@upmc.edu
Key Words	Neuroendocrine neoplasm; Large cell neuroendocrine carcinoma; Small cell neuroendocrine carcinoma; Extrahepatic bile duct; Dysplasia
Core Tip	The authors report a case of large-cell neu-roendocrine carcinoma (LCNEC) of the hilar bile duct. Concurrent dysplasia with intestinal and neuroendocrine differentiation was suggested to be a precursor in this case. Neuroendocrine carcinoma (NEC) of the bile duct occurs more frequently in men (male:female ratio 1.9:1). The mid-portion of the common bile duct appears to be the commonest site of involvement. All three reported cases of LCNEC died within 12 mo and the prognosis of NEC of the bile duct appears to be equally poor in both small-cell NEC and LCNEC. Multimodal treatment may improve outcome in this highly aggressive cancer.
Publish Date	2013-07-29 11:18
Citation	Sasatomi E, Nalesnik MA, Marsh JW. Neuroendocrine carcinoma of the extrahepatic bile duct: Case report and literature review. World J Gastroenterol 2013; 19(28): 4616-4623
URL	http://www.wjgnet.com/1007-9327/full/v19/i28/4616.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i28.4616

Full Article (PDF)	WJG-19-4616.pdf
Manuscript File	1654-Review.doc
Answering Reviewers	1654-Answering reviewers.docx
Copyright License Agreement	1654-Copyright assignment.docx
Peer-review Report	1654-Peer review.pdf
Scientific Editor Work List	1654-Scientific editor work list.doc