Publication Name	World Journal of Stem Cells
Manuscript ID	16540
Country	United States

Received	2015-01-22 08:53
Peer-Review Started	2015-01-22 14:05
To Make the First Decision	2015-03-06 10:14
Return for Revision	2015-03-15 15:23
Revised	2015-04-02 09:21
Second Decision	2015-09-29 17:25
Accepted by Journal Editor-in-Chief	2015-09-30 08:53
Accepted by Executive Editor-in-Chief	2015-10-13 17:28
Articles in Press	2015-10-13 17:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-04 18:34
Publish the Manuscript Online	2015-11-27 14:51

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Review
Article Title	Dedifferentiated fat cells: A cell source for regenerative medicine
Manuscript Source	Invited Manuscript
All Author List	Medet Jumabay and Kristina I Boström
Funding Agency and Grant Number	Funding Agency Grant Number American Heart Association to Medet Jumabay NIH P01 HL30568(to Kristina I Boström) NIH R01 HL81397(to Kristina I Boström) NIH R01 HL112839 (to Kristina I Boström)
Corresponding Author	Medet Jumabay, MD, PhD, Division of Cardiology, David Geffen School of Medicine at UCLA, Box 951679, Los Angeles, CA 90095-1679, United States. mjumabay@mednet.ucla.edu
Key Words	Adipocytes; Dedifferentiated fat cells; Adult stem cells; Pluripotent stem cells; Differentiation
Core Tip	Multipotent dedifferentiated fat (DFAT) cells provide evidence of plasticity in adipocytes. The newly established DFAT cells exhibit vigorous proliferation and multipotent abilities with advantages over other adult stem cells. Modified culture methods reduce the risk of contamination by cells from the stromal vascular fraction to a minimum. In in vitro and/or in vivo experiments have revealed adipogenic, osteogenic, chondrogenic, myogenic, angiogenic and neourogenic potentials in DFAT cells. Moreover, the DFAT cells express embryonic stem cell markers and are similar to induced pluripotent stem cells in certain physiological aspects. Based on the abundance, ease of preparation, homogeneity, and multi-lineage potential, the DFAT cells are uniquely suited for regenerative medicine.
Publish Date	2015-11-27 14:51
Citation	Jumabay M, Boström KI. Dedifferentiated fat cells: A cell source for regenerative medicine. World J Stem Cells 2015; 7(10): 1202-1214
URL	http://www.wjgnet.com/1948-0210/full/v7/i10/1202.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i10.1202

Full Article (PDF)	WJSC-7-1202.pdf
Full Article (Word)	WJSC-7-1202.doc
Manuscript File	16540-Review.docx
Answering Reviewers	16540-Answering reviewers.pdf
Audio Core Tip	16540-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16540-Conflict-of-interest statement.pdf
Copyright License Agreement	16540-Copyright assignment.pdf
Peer-review Report	16540-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16540-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16540-Scientific misconduct check.pdf
Scientific Editor Work List	16540-Scientific editor work list.pdf