Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	16559
Country	Italy

Received	2015-01-23 08:41
Peer-Review Started	2015-02-01 16:55
To Make the First Decision	2015-03-06 10:13
Return for Revision	2015-03-15 16:06
Revised	2015-03-20 03:29
Second Decision	2015-09-02 10:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-08 15:42
Articles in Press	2015-09-08 15:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-19 10:07
Publish the Manuscript Online	2015-11-10 12:29

ISSN	2219-2808 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Rheumatology
Manuscript Type	Minireviews
Article Title	Fever tree revisited: From malaria to autoinflammatory diseases
Manuscript Source	Invited Manuscript
All Author List	Serena Pastore, Josef Vuch, Anna Monica Bianco, Andrea Taddio and Alberto Tommasini
Funding Agency and Grant Number
Corresponding Author	Alberto Tommasini, MD, PhD, Department of Pediatrics, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34137 Trieste, Italy. alberto.tommasini@burlo.trieste.it
Key Words	Recurrent fevers; Malaria; Autoinflammatory diseases; Periodic fever adenitis pharyngytis aphthe syndrome; History of medicine; Interleukin-1; Genetics; The fever tree
Core Tip	Periodic fevers of autoinflammatory nature have been increasingly recognized in recent decades, in many cases reflecting monogenic disorders of inflammation. However, patients can be encountered in clinical practice who don’t fit in any definite category of periodic fever, despite of extensive molecular analyses. A clinical approach based on the analogy with the well defined monogenic diseases can be reasonable in these cases, which likely represent an heterogeneous group of multifactorial disorders. We propose revising the historical image of the fever tree to figure the possible existence of a disease continuum between multifactorial and monogenic periodic fever syndromes.
Publish Date	2015-11-10 12:29
Citation	Pastore S, Vuch J, Bianco AM, Taddio A, Tommasini A. Fever tree revisited: From malaria to autoinflammatory diseases. World J Clin Pediatr 2015; 4(4): 106-112
URL	http://www.wjgnet.com/2219-2808/full/v4/i4/106.htm
DOI	http://dx.doi.org/10.5409/wjcp.v4.i4.106

Full Article (PDF)	WJCP-4-106.pdf
Full Article (Word)	WJCP-4-106.doc
Manuscript File	16559-Review.docx
Answering Reviewers	16559-Answering reviewers.pdf
Audio Core Tip	16559-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16559-Conflict-of-interest statement.pdf
Copyright License Agreement	16559-Copyright assignment.pdf
Peer-review Report	16559-Peer-review(s).pdf
Scientific Misconduct Check	16559-Scientific misconduct check.pdf
Scientific Editor Work List	16559-Scientific editor work list.pdf