Publication Name	World Journal of Gastroenterology
Manuscript ID	16716
Country	Italy

Received	2015-01-28 10:43
Peer-Review Started	2015-01-28 20:57
To Make the First Decision	2015-02-10 15:52
Return for Revision	2015-02-13 11:24
Revised	2015-02-24 22:55
Second Decision	2015-03-25 17:09
Accepted by Journal Editor-in-Chief	2015-03-26 07:10
Accepted by Executive Editor-in-Chief	2015-03-31 10:13
Articles in Press	2015-03-31 11:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-17 09:46
Publish the Manuscript Online	2015-05-13 10:38

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Liver plays a central role in asymmetric dimethylarginine-mediated organ injury
Manuscript Source	Invited Manuscript
All Author List	Andrea Ferrigno, Laura G Di Pasqua, Clarissa Berardo, Plinio Richelmi and Mariapia Vairetti
Funding Agency and Grant Number	Funding Agency Grant Number Fondazione Cariplo 2011-0439
Corresponding Author	Mariapia Vairetti, PhD, Department of Internal Medicine and Therapeutics, University of Pavia, Via Ferrata 9A, 27100 Pavia, Italy. mariapia.vairetti@unipv.it
Key Words	Liver; Asymmetric dimethylarginine; Nitric oxide; NO-synthase; Multiple organ failure
Core Tip	Nitric oxide (NO) synthesis is blocked by asymmetric dimethylarginine (ADMA) which competes with L-arginine for NO-synthase. ADMA is metabolized principally in the liver, by dimethylarginine dimethy?laminohydrolase. The kidney and the liver are involved in ADMA excretion. A correlation exists between plasma ADMA levels and degree of hepatic dysfunction in patients suffering from liver cirrhosis, alcoholic hepatitis and acute liver failure. High plasma ADMA levels are relevant because they are associated with the development of multi-organ failure (MOF): increased plasma ADMA concentration was identified as a risk factor for MOF in critically-ill patients causing enhanced Intensive Care Unit mortality.
Publish Date	2015-05-13 10:38
Citation	Ferrigno A, Di Pasqua LG, Berardo C, Richelmi P, Vairetti M. Liver plays a central role in asymmetric dimethylarginine-mediated organ injury. World J Gastroenterol 2015; 21(17): 5131-5137
URL	http://www.wjgnet.com/1007-9327/full/v21/i17/5131.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i17.5131

Full Article (PDF)	WJG-21-5131.pdf
Full Article (Word)	WJG-21-5131.doc
Manuscript File	16716-Review.docx
Answering Reviewers	16716-Answering reviewers.pdf
Audio Core Tip	16716-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16716-Conflict-of-interest statement.pdf
Copyright License Agreement	16716-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20150127232159.pdf
Peer-review Report	16716-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16716-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16716-Scientific misconduct check.pdf
Scientific Editor Work List	16716-Scientific editor work list.pdf