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5/13/2015 10:38:00 AM | Browse: 804 | Download: 1181
Publication Name World Journal of Gastroenterology
Manuscript ID 16716
Country/Territory Italy
Received
2015-01-28 10:43
Peer-Review Started
2015-01-28 20:57
To Make the First Decision
2015-02-10 15:52
Return for Revision
2015-02-13 11:24
Revised
2015-02-24 22:55
Second Decision
2015-03-25 17:09
Accepted by Journal Editor-in-Chief
2015-03-26 07:10
Accepted by Company Editor-in-Chief
2015-03-31 10:13
Articles in Press
2015-03-31 11:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-04-17 09:46
Publish the Manuscript Online
2015-05-13 10:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Editorial
Article Title Liver plays a central role in asymmetric dimethylarginine-mediated organ injury
Manuscript Source Invited Manuscript
All Author List Andrea Ferrigno, Laura G Di Pasqua, Clarissa Berardo, Plinio Richelmi and Mariapia Vairetti
Funding Agency and Grant Number
Funding Agency Grant Number
Fondazione Cariplo 2011-0439
Corresponding Author Mariapia Vairetti, PhD, Department of Internal Medicine and Therapeutics, University of Pavia, Via Ferrata 9A, 27100 Pavia, Italy. mariapia.vairetti@unipv.it
Key Words Liver; Asymmetric dimethylarginine; Nitric oxide; NO-synthase; Multiple organ failure
Core Tip Nitric oxide (NO) synthesis is blocked by asymmetric dimethylarginine (ADMA) which competes with L-arginine for NO-synthase. ADMA is metabolized principally in the liver, by dimethylarginine dimethy?laminohydrolase. The kidney and the liver are involved in ADMA excretion. A correlation exists between plasma ADMA levels and degree of hepatic dysfunction in patients suffering from liver cirrhosis, alcoholic hepatitis and acute liver failure. High plasma ADMA levels are relevant because they are associated with the development of multi-organ failure (MOF): increased plasma ADMA concentration was identified as a risk factor for MOF in critically-ill patients causing enhanced Intensive Care Unit mortality.
Publish Date 2015-05-13 10:38
Citation Ferrigno A, Di Pasqua LG, Berardo C, Richelmi P, Vairetti M. Liver plays a central role in asymmetric dimethylarginine-mediated organ injury. World J Gastroenterol 2015; 21(17): 5131-5137
URL http://www.wjgnet.com/1007-9327/full/v21/i17/5131.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i17.5131
Full Article (PDF) WJG-21-5131.pdf
Full Article (Word) WJG-21-5131.doc
Manuscript File 16716-Review.docx
Answering Reviewers 16716-Answering reviewers.pdf
Audio Core Tip 16716-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 16716-Conflict-of-interest statement.pdf
Copyright License Agreement 16716-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate Editing_Certificate_20150127232159.pdf
Peer-review Report 16716-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16716-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16716-Scientific misconduct check.pdf
Scientific Editor Work List 16716-Scientific editor work list.pdf