Publication Name	World Journal of Biological Chemistry
Manuscript ID	16771
Country	France

Received	2015-01-29 09:18
Peer-Review Started	2015-02-01 13:33
To Make the First Decision	2015-03-20 14:31
Return for Revision	2015-03-28 16:29
Revised	2015-04-27 20:47
Second Decision	2015-05-07 09:50
Accepted by Journal Editor-in-Chief	2015-05-07 16:15
Accepted by Executive Editor-in-Chief	2015-05-18 16:59
Articles in Press	2015-05-18 17:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-03 12:03
Publish the Manuscript Online	2015-08-26 11:07

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Essential roles of four-carbon backbone chemicals in the control of metabolism
Manuscript Source	Invited Manuscript
All Author List	Sabrina Chriett and Luciano Pirola
Funding Agency and Grant Number
Corresponding Author	Dr. Luciano Pirola, INSERM Unit 1060, South Lyon Hospital, Medical Faculty, CarMeN Laboratory, Lyon-1 University, INRA U1397, 165 Ch. du Grand Revoyet - BP12, 69921 Oullins, France. luciano.pirola@univ-lyon1.fr
Key Words	Butyric acid; D-β-hydroxybutyrate; Histone deacetylases; Histone deacetylases inhibitors; Insulin resistance
Core Tip	Recent research demonstrated that the four-carbon molecule butyrate, and butyrate-related molecules (4-phenylbutyric acid, D-β-hydroxybutyrate and β-aminoisobutyric acid), act as modulators of metabolism, favoring energy expenditure. Conversely, another butyrate-related molecule, α-hydroxybutyrate, is an early predictor of insulin resistance and glucose intolerance. In this minireview, we summarize the recent progress in the understanding of the mechanism of action of these molecules and discuss their possible therapeutic use to improve metabolic homeostasis and their usefulness as early biomarkers for insulin resistance.
Publish Date	2015-08-26 11:07
Citation	Chriett S, Pirola L. Essential roles of four-carbon backbone chemicals in the control of metabolism. World J Biol Chem 2015; 6(3): 223-230
URL	http://www.wjgnet.com/1949-8454/full/v6/i3/223.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i3.223

Full Article (PDF)	WJBC-6-223.pdf
Full Article (Word)	WJBC-6-223.doc
Manuscript File	16771-Review.docx
Answering Reviewers	16771-Answering reviewers.pdf
Audio Core Tip	16771-Audio core tip.wav
Conflict-of-Interest Disclosure Form	16771-Conflict-of-interest statement.pdf
Copyright License Agreement	16771-Copyright assignment.pdf
Peer-review Report	16771-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16771-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16771-Scientific misconduct check.pdf
Scientific Editor Work List	16771-Scientific editor work list.pdf