Publication Name	World Journal of Gastroenterology
Manuscript ID	16778
Country	Italy

Received	2015-01-29 08:43
Peer-Review Started	2015-01-29 11:17
To Make the First Decision	2015-03-10 17:44
Return for Revision	2015-03-12 10:43
Revised	2015-04-09 16:33
Second Decision	2015-04-28 08:05
Accepted by Journal Editor-in-Chief	2015-04-28 17:10
Accepted by Executive Editor-in-Chief	2015-05-04 17:33
Articles in Press	2015-05-04 17:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-02 13:34
Publish the Manuscript Online	2015-06-29 16:33

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Editorial
Article Title	Effector and suppressor T cells in celiac disease
Manuscript Source	Invited Manuscript
All Author List	Giuseppe Mazzarella
Funding Agency and Grant Number
Corresponding Author	Giuseppe Mazzarella, DSC, Immuno-Morphology Lab, Institute of Food Sciences, National Council Research, Via Roma 64, 83100 Avellino, Italy. gmazzarella@isa.cnr.it
Key Words	Celiac disease; Th1 cells; Th17 cells; Treg cells
Core Tip	Although it is evident that effector gliadin-specific Th1 cells play an important role in celiac disease (CD) pathogenesis, recent studies have implicated Th17 effector cells in the disease process. Contrasting evidence has been reported on the ability of gliadin-specific cells to produce IL-17A. In addition, regulatory T cells, formerly known as suppressor T cells, have been identified in intestinal biopsy specimens of patients with active CD. Nevertheless, despite the presence of an endogenous counter-regulatory mechanism in the intestinal mucosa of celiac patients, the inflammatory response is not suppressed. In this review, we provide an overview of the current knowledge of the contribution of both Th1 and Th17 effector T cells and Treg cells in controlling mucosal inflammation in CD.
Publish Date	2015-06-29 16:33
Citation	Mazzarella G. Effector and suppressor T cells in celiac disease. World J Gastroenterol 2015; 21(24): 7349-7356
URL	http://www.wjgnet.com/1007-9327/full/v21/i24/7349.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i24.7349

Full Article (PDF)	WJG-21-7349.pdf
Full Article (Word)	WJG-21-7349.doc
Manuscript File	16778-Review.docx
Answering Reviewers	16778-Answering reviewers.pdf
Audio Core Tip	16778-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16778-Conflict-of-interest statement.pdf
Copyright License Agreement	16778-Copyright assignment.pdf
Peer-review Report	16778-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16778-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16778-Scientific misconduct check.pdf
Scientific Editor Work List	16778-Scientific editor work list.pdf