Publication Name	World Journal of Gastroenterology
Manuscript ID	16810
Country	United States

Received	2015-01-29 21:10
Peer-Review Started	2015-01-30 21:42
To Make the First Decision	2015-04-13 15:52
Return for Revision	2015-04-14 10:34
Revised	2015-04-28 12:49
Second Decision	2015-08-27 19:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-08-31 11:59
Articles in Press	2015-08-31 11:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-06 15:25
Publish the Manuscript Online	2015-09-28 18:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Microbiome as mediator: Do systemic infections start in thegut?
Manuscript Source	Invited Manuscript
All Author List	Melissa Latorre, Suneeta Krishnareddy and Daniel E Freedberg
Funding Agency and Grant Number
Corresponding Author	Daniel E Freedberg, MD, Assistant Professor of Medicine, Division of Digestive and Liver Diseases, Columbia University Medical Center, 630 West 168th Street, PH7, New York, NY 10023, United States. def2004@cumc.columbia.edu
Key Words	Clostridium difficile; Gut; Microbiome; Critical illness; Short-chain fatty acids; Probiotics
Core Tip	The role of the intestinal microbiome in the development and treatment of Clostridium difficile (C. difficile) infection is well established. However, the intestinal microbiome is emerging as a crucial mediator in the development of systemic disease and non-gastrointestinal infection. If the pathways linking gut bacteria to systemic infections can be elucidated, it may become possible to intervene upon the microbiome before disease occurs. This understanding would move clinicians beyond fecal microbial transplant for C. difficile infection to paradigm-changing treatments for gut-derived systemic infections.
Publish Date	2015-09-28 18:06
Citation	Latorre M, Krishnareddy S, Freedberg DE. Microbiome as mediator: Do systemic infections start in the gut? World J Gastroenterol 2015; 21(37): 10487-10492
URL	http://www.wjgnet.com/1007-9327/full/v21/i37/10487.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i37.10487

Full Article (PDF)	WJG-21-10487.pdf
Full Article (Word)	WJG-21-10487.doc
Manuscript File	16810-Review.docx
Answering Reviewers	16810-Answering reviewers.pdf
Audio Core Tip	16810-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16810-Conflict-of-interest statement.pdf
Copyright License Agreement	16810-Copyright assignment.pdf
Peer-review Report	16810-Peer-review(s).pdf
Scientific Misconduct Check	16810-Scientific misconduct check.pdf
Scientific Editor Work List	16810-Scientific editor work list.pdf