Publication Name	World Journal of Biological Chemistry
Manuscript ID	16986
Country	United States

Received	2015-02-05 11:06
Peer-Review Started	2015-02-07 19:28
To Make the First Decision	2015-03-20 11:41
Return for Revision	2015-03-28 15:45
Revised	2015-04-23 02:12
Second Decision	2015-04-30 16:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-05-08 16:18
Articles in Press	2015-05-08 16:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-07 14:37
Publish the Manuscript Online	2015-08-26 11:07

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Topographic patterns of vascular disease: HOX proteins as determining factors?
Manuscript Source	Invited Manuscript
All Author List	Richard P Visconti and Alexander Awgulewitsch
Funding Agency and Grant Number	Funding Agency Grant Number National Institute of General Medical Sciences of the National Institute of Health P20GM109040 National Institute of General Medical Sciences of the National Institute of Health P20GM103444 National Institute of General Medical Sciences of the National Institute of Health P30GM103342 RII grant from the NSF EPS-0903795 American Heart Association 2BGIA 11720004 South Carolina EPSCoR grant for Exploratory Academic Research 15-2843
Corresponding Author	Alexander Awgulewitsch, PhD, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 96 Jonathan Lucas Street, STE 816, Charleston, SC 29425, United States. awgulewa@musc.edu
Key Words	Hox; Blood vessel; Cardiovascular disease; Positional identity; Endothelial cell; Vascular smooth muscle cell
Core Tip	Accumulating evidence indicates regionally restricted HOX expression patterns in the adult arterial tree that may reflect a topographic vascular HOX code for specifying positional identities in various cell types of the circulatory system. We propose that this positional information is critical for maintaining local vessel wall homeostasis and that its disruption plays an important role in the development of vascular diseases with distinct topographic preferences. This editorial discusses emerging molecular data in support of this novel concept.
Publish Date	2015-08-26 11:07
Citation	Visconti RP, Awgulewitsch A. Topographic patterns of vascular disease: HOX proteins as determining factors? World J Biol Chem 2015; 6(3): 65-70
URL	http://www.wjgnet.com/1949-8454/full/v6/i3/65.htm
DOI	http://www.wjgnet.com/1949-8454/full/v6/i3/65.htm

Manuscript File	16986-Review.docx
Answering Reviewers	16986-Answering reviewers.pdf
Audio Core Tip	16986-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16986-Conflict-of-interest statement.PDF
Copyright License Agreement	16986-Copyright assignment.pdf
Peer-review Report	16986-Peer-review(s).pdf
Scientific Misconduct Check	16986-Scientific misconduct check.pdf
Scientific Editor Work List	16986-Scientific editor work list.pdf