Publication Name	World Journal of Gastroenterology
Manuscript ID	17011
Country	Germany

Received	2015-02-06 16:13
Peer-Review Started	2015-02-07 10:28
To Make the First Decision	2015-05-18 12:32
Return for Revision	2015-05-19 15:29
Revised
Second Decision	2015-09-12 21:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-09-14 10:58
Articles in Press	2015-09-14 10:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-11 17:14
Publish the Manuscript Online	2015-11-27 14:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Allergy
Manuscript Type	Frontier
Article Title	Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Emilio G Quetglas, Zlatan Mujagic, Simone Wigge, Daniel Keszthelyi, Sebastian Wachten, Ad Masclee and Walter Reinisch
Funding Agency and Grant Number
Corresponding Author	Emilio G Quetglas, MD, PhD, Project Strategy and Science, Grünenthal GmbH, 52078 Aachen, Germany. emilio.quetglas@grunenthal.com
Key Words	Mucosal immunology; Biomarkers; Pharmacology; Mode of action; Therapeutic drug monitoring
Core Tip	The following article is an update on the latest findings on the pathogenesis of inflammatory bowel disease (IBD) and its correlation with genetic and non-genetic predictors of the efficacy of the different strategies of treatment. Although many therapies have been used for decades, this is a completely new approach that has become even more complicated with new therapies like biologics. While most of these strategies are still in a very early stage, and have not been validated in clinical practice, they have begun suggesting the direction in which physicians should start looking to establish the most adequate therapeutic strategy for each individual patient.
Publish Date	2015-11-27 14:01
Citation	Quetglas EG, Mujagic Z, Wigge S, Keszthelyi D, Wachten S, Masclee A, Reinisch W. Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease. World J Gastroenterol 2015; 21(44): 12519-12543
URL	http://www.wjgnet.com/1007-9327/full/v21/i44/12519.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i44.12519

Full Article (PDF)	WJG-21-12519.pdf
Full Article (Word)	WJG-21-12519.doc
Manuscript File	17011-Review.docx
Answering Reviewers	17011-Answering reviewers.pdf
Audio Core Tip	17011-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17011-Conflict-of-interest statement.pdf
Copyright License Agreement	17011-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	17011-Language certificate.pdf
Supplementary Material	Supplementary_Material_20150206161103.pdf
Peer-review Report	17011-Peer-review(s).pdf
Scientific Misconduct Check	17011-Scientific misconduct check.pdf
Scientific Editor Work List	17011-Scientific editor work list.pdf