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9/24/2015 6:44:00 PM | Browse: 472 | Download: 642
Publication Name World Journal of Transplantation
Manuscript ID 17215
Country/Territory United States
Received
2015-02-25 10:18
Peer-Review Started
2015-02-26 10:39
To Make the First Decision
2015-06-03 14:39
Return for Revision
2015-06-04 16:31
Revised
2015-06-11 00:02
Second Decision
2015-08-07 17:48
Accepted by Journal Editor-in-Chief
2015-08-08 18:49
Accepted by Company Editor-in-Chief
2015-08-14 16:20
Articles in Press
2015-08-14 16:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-09-14 21:45
Publish the Manuscript Online
2015-09-24 18:44
ISSN 2220-3230 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Retrospective Study
Article Title Role of steroid maintenance in sensitized kidney transplant recipients
Manuscript Source Invited Manuscript
All Author List Kalathil K Sureshkumar, Richard J Marcus and Bhavna Chopra
Funding Agency and Grant Number
Corresponding author Kalathil K Sureshkumar, MD, FRCP (Glasgow), FASN, Division of Nephrology and Hypertension, Department of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, United States. ksureshk@wpahs.org
Keywords Sensitization; Kidney transplantation; Graft survival; Steroid withdrawal; Older kidney transplant recipients
Core Tip This study critically evaluated the role of steroid maintenance in kidney transplant recipients (KTR) based on the level of sensitization by utilizing the Organ Procurement and Transplant Network/United Network of Organ Sharing database. In the multivariate model, we found an association between increased risk for death with functioning graft and steroid maintenance in KTRs who had peak-panel reactive antibody < 30% and received perioperative induction therapy followed by calcineurin inhibitor/mycophenolate mofetil maintenance. On the other hand, steroid maintenance was associated with improved death-censored graft survival without adversely impacting patient survival in KTRs with a peak PRA > 60%. No benefits of steroid maintenance were observed in older KTRs regardless of level of sensitization. These finding have clinical relevance and should be further evaluated in randomized clinical trials.
Publish Date 2015-09-24 18:44
Citation Sureshkumar KK, Marcus RJ, Chopra B. Role of steroid maintenance in sensitized kidney transplant recipients. World J Transplant 2015; 5(3): 102-109
Url http://www.wjgnet.com/2220-3230/full/v5/i3/102.htm
DOI http://dx.doi.org/10.5500/wjt.v5.i3.102
Full Article (PDF) WJT-5-102.pdf
Full Article (Word) WJT-5-102.doc
Manuscript File 17215-Review.docx
Answering Reviewers 17215-Answering reviewers.PDF
Audio Core Tip 17215-Audio core tip.m4a
Biostatistics Review Certificate 17215-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 17215-Conflict-of-interest statement.PDF
Copyright License Agreement 17215-Copyright assignment.PDF
Data Sharing Statement 17215-Data sharing statement.PDF
Institutional Review Board Approval Form or Document 17215-Institutional review board statement.PDF
Peer-review Report 17215-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 17215-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 17215-Scientific misconduct check.pdf
Scientific Editor Work List 17215-Scientific editor work list.pdf