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9/24/2015 6:44:00 PM | Browse: 902 | Download: 1198
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Received |
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2015-02-25 10:18 |
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Peer-Review Started |
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2015-02-26 10:39 |
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To Make the First Decision |
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2015-06-03 14:39 |
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Return for Revision |
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2015-06-04 16:31 |
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Revised |
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2015-06-11 00:02 |
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Second Decision |
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2015-08-07 17:48 |
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Accepted by Journal Editor-in-Chief |
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2015-08-08 18:49 |
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Accepted by Company Editor-in-Chief |
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2015-08-14 16:20 |
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Articles in Press |
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2015-08-14 16:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-09-14 21:45 |
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Publish the Manuscript Online |
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2015-09-24 18:44 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Retrospective Study |
| Article Title |
Role of steroid maintenance in sensitized kidney transplant recipients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kalathil K Sureshkumar, Richard J Marcus and Bhavna Chopra |
| Funding Agency and Grant Number |
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| Corresponding Author |
Kalathil K Sureshkumar, MD, FRCP (Glasgow), FASN, Division of Nephrology and Hypertension, Department of Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, United States. ksureshk@wpahs.org |
| Key Words |
Sensitization; Kidney transplantation; Graft survival; Steroid withdrawal; Older kidney transplant recipients |
| Core Tip |
This study critically evaluated the role of steroid maintenance in kidney transplant recipients (KTR) based on the level of sensitization by utilizing the Organ Procurement and Transplant Network/United Network of Organ Sharing database. In the multivariate model, we found an association between increased risk for death with functioning graft and steroid maintenance in KTRs who had peak-panel reactive antibody < 30% and received perioperative induction therapy followed by calcineurin inhibitor/mycophenolate mofetil maintenance. On the other hand, steroid maintenance was associated with improved death-censored graft survival without adversely impacting patient survival in KTRs with a peak PRA > 60%. No benefits of steroid maintenance were observed in older KTRs regardless of level of sensitization. These finding have clinical relevance and should be further evaluated in randomized clinical trials. |
| Publish Date |
2015-09-24 18:44 |
| Citation |
Sureshkumar KK, Marcus RJ, Chopra B. Role of steroid maintenance in sensitized kidney transplant recipients. World J Transplant 2015; 5(3): 102-109 |
| URL |
http://www.wjgnet.com/2220-3230/full/v5/i3/102.htm |
| DOI |
http://dx.doi.org/10.5500/wjt.v5.i3.102 |
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