BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/17/2015 8:51:00 AM | Browse: 441 | Download: 546
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 17226
Country/Territory Japan
Received
2015-02-25 09:53
Peer-Review Started
2015-02-26 11:37
To Make the First Decision
2015-03-26 18:03
Return for Revision
2015-03-30 13:50
Revised
2015-04-06 10:01
Second Decision
2015-08-03 19:16
Accepted by Journal Editor-in-Chief
2015-08-06 09:34
Accepted by Company Editor-in-Chief
2015-08-28 09:52
Articles in Press
2015-08-28 11:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-22 21:26
Publish the Manuscript Online
2015-11-17 08:51
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Topic Highlights
Article Title Clinical significance of MET in gastric cancer
Manuscript Source Invited Manuscript
All Author List Mikito Inokuchi, Sho Otsuki, Yoshitaka Fujimori, Yuya Sato, Masatoshi Nakagawa and Kazuyuki Kojima
Funding Agency and Grant Number
Corresponding author Mikito Inokuchi, MD, PhD, Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. m-inokuchi.srg2@tmd.ac.jp
Keywords MET; Gastric cancer; Genomic amplification; Immunohistochemistry; Clinical trial
Core Tip MET protein overexpression or MET gene amplification was associated with tumor progression and survival in gastric cancer (GC), although the definition of MET overexpression remains to be standardized. In preclinical studies, MET antibodies or small-molecule MET inhibitors suppressed cell proliferation and tumor progression in MET-amplified GC cells. Therefore, MET-targeting therapy is promising, and MET overexpression might be a useful biomarker of the response to chemotherapy inhibiting MET. Some clinical trials of MET inhibitors were conducted in metastatic GC, but sufficient benefits have not been demonstrated yet.
Publish Date 2015-11-17 08:51
Citation Inokuchi M, Otsuki S, Fujimori Y, Sato Y, Nakagawa M, Kojima K. Clinical significance of MET in gastric cancer. World J Gastrointest Oncol 2015; 7(11): 317-327
Url http://www.wjgnet.com/1948-5204/full/v7/i11/317.htm
DOI http://dx.doi.org/10.4251/wjgo.v7.i11.317
Full Article (PDF) WJGO-7-317.pdf
Full Article (Word) WJGO-7-317.doc
Manuscript File 17226-Review.docx
Answering Reviewers 17226-Answering reviewers.pdf
Audio Core Tip 17226-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 17226-Conflict-of-interest statement.pdf
Copyright License Agreement 17226-Copyright assignment.pdf
Peer-review Report 17226-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 17226-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 17226-Scientific misconduct check.pdf
Scientific Editor Work List 17226-Scientific editor work list.pdf