Publication Name	World Journal of Biological Chemistry
Manuscript ID	17345
Country	United States

Received	2015-03-03 08:32
Peer-Review Started	2015-03-04 20:33
To Make the First Decision	2015-05-13 19:16
Return for Revision	2015-05-19 16:26
Revised	2015-06-03 11:11
Second Decision	2015-07-06 08:36
Accepted by Journal Editor-in-Chief	2015-07-06 18:57
Accepted by Executive Editor-in-Chief	2015-08-03 15:49
Articles in Press	2015-08-03 15:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-07 16:03
Publish the Manuscript Online	2015-08-26 11:07

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Editorial
Article Title	Mechanism of DNA damage tolerance
Manuscript Source	Invited Manuscript
All Author List	Xin Bi
Funding Agency and Grant Number	Funding Agency Grant Number United States National Science Foundation MCB-1158008
Corresponding Author	Xin Bi, PhD, Professor, Department of Biology, University of Rochester, Rochester, NY 14627, United States. xin.bi@rochester.edu
Key Words	DNA damage tolerance; Template switching; DNA damage bypass; DNA replication; Replicative stress; Translesion synthesis; Ubiquitination; Sumoylation
Core Tip	DNA damage may compromise genome in?tegrity and lead to cell death. Cells have evolved a variety of processes to respond to DNA damage including damage repair and tolerance mechanisms. The DNA damage tolerance (DDT) pathway promotes the bypass of single-stranded DNA lesions encountered by DNA polymerases during DNA replication. This prevents the stalling of DNA replication. Two mechanistically distinct DDT branches, translesion synthesis and template switching have been characterized. However, our current understanding of DDT is far from complete and that of template switching is especially sketchy. This editorial focuses on recently identified components and regulators of DDT.
Publish Date	2015-08-26 11:07
Citation	Bi X. Mechanism of DNA damage tolerance. World J Biol Chem 2015; 6(3): 48-56
URL	http://www.wjgnet.com/1949-8454/full/v6/i3/48.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i3.48

Full Article (PDF)	WJBC-6-48.pdf
Full Article (Word)	WJBC-6-48.doc
Manuscript File	17345-Review.docx
Answering Reviewers	17345-Answering reviewers.pdf
Audio Core Tip	17345-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17345-Conflict-of-interest statement.pdf
Copyright License Agreement	17345-Copyright assignment.pdf
Peer-review Report	17345-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17345-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17345-Scientific misconduct check.pdf
Scientific Editor Work List	17345-Scientific editor work list.pdf