| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Lymphocyte-to-monocyte ratio predicts survival of patients with hepatocellular carcinoma after curative resection
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ze-Xiao Lin, Dan-Yun Ruan, Yang Li, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen and Xiang-Yuan Wu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81372374 |
| Combination Project of Production, Education and Research from Guangdong Province and Ministry of Education |
2012B091100460 |
| Natural Science Foundation of Guangdong |
2014A030313146 |
|
| Corresponding Author |
Xiang-Yuan Wu, MD, Professor, Chief, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. wuxiangy@mail.sysu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Liver resection; Lymphocyte-to-monocyte ratio; Prognosis; Prognostic factor |
| Core Tip |
Inflammatory microenvironment plays an important role in the progression of hepatocellular carcinoma (HCC). Peripheral blood lymphocyte-to-monocyte ratio (LMR), a novel inflammatory biomarker that combines estimates of host immune homeostasis and tumor microenvironment, has been found to serve as a predictor of clinical outcomes in various malignancies. Prior to this study, there have been no reports regarding the prognostic value of LMR in HCC patients. For the first time in literature, our study identified the optimal cutoff value of LMR for survival analysis and concluded that preoperative LMR could serve as an independent prognostic factor in hepatitis B virus-associated HCC patients after curative resection. |
| Publish Date |
2015-10-14 12:06 |
| Citation |
Lin ZX, Ruan DY, Li Y, Wu DH, Ma XK, Chen J, Chen ZH, Li X, Wang TT, Lin Q, Wen JY, Wu XY. Lymphocyte-to-monocyte ratio predicts survival of patients with hepatocellular carcinoma after curative resection. World J Gastroenterol 2015; 21(38): 10898-10906 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i38/10898.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i38.10898 |
