Publication Name	World Journal of Orthopedics
Manuscript ID	17485
Country	United States

Received	2015-03-10 08:40
Peer-Review Started	2015-03-12 08:44
To Make the First Decision	2015-03-20 11:44
Return for Revision	2015-03-27 15:22
Revised	2015-04-17 20:25
Second Decision	2015-05-08 17:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-05-18 17:24
Articles in Press	2015-05-18 17:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-30 18:50
Publish the Manuscript Online	2015-07-14 18:18

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Bone graft substitutes for spine fusion: A brief review
Manuscript Source	Invited Manuscript
All Author List	Ashim Gupta, Nitin Kukkar, Kevin Sharif, Benjamin J Main, Christine E Albers and Saadiq F El-Amin III
Funding Agency and Grant Number
Corresponding Author	Saadiq F El-Amin III, MD, PhD, Division of Orthopaedics and Rehabilitation, Department of Surgery, Southern Illinois University School of Medicine, 701 North First Street, Springfield, IL 62794, United States. sel-amin@siumed.edu
Key Words	Bone enhancers; Bone graft substitutes; Spine fusion; Autograft; Allograft
Core Tip	In this review, we discussed the biology of spine fusion and the current advances in biomedical materials and biological strategies for application in surgical spine fusion. Our findings illustrate that, while many bone graft substitutes perform well as bone graft extenders, only osteoinductive proteins (recombinant bone morphogenetic proteins-2 and osteogenic protein-1) provide evidence for use as both bone enhancers and bone substitutes for specific types of spinal fusion. Tissue engineered hydrogels, synthetic polymer composites and viral based gene therapy also holds the potential to be used for spine fusion in the future, though further investigation is needed before being used in clinical practice.
Publish Date	2015-07-14 18:18
Citation	Gupta A, Kukkar N, Sharif K, Main BJ, Albers CE, El-Amin III SF. Bone graft substitutes for spine fusion: A brief review. World J Orthop 2015; 6(6): 449-456
URL	http://www.wjgnet.com/2218-5836/full/v6/i6/449.htm
DOI	http://dx.doi.org/10.5312/wjo.v6.i6.449

Full Article (PDF)	WJO-6-449.pdf
Full Article (Word)	WJO-6-449.doc
Manuscript File	17485-Review.docx
Answering Reviewers	17485-Answering reviewers.pdf
Audio Core Tip	17485-Audio core tip.mp4
Conflict-of-Interest Disclosure Form	17485-Conflict-of-interest statement.pdf
Copyright License Agreement	17485-Copyright assignment.pdf
Peer-review Report	17485-Peer-review(s).pdf
Scientific Misconduct Check	17485-Scientific misconduct check.pdf
Scientific Editor Work List	17485-Scientific editor work list.pdf