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Articles Published Processes
6/29/2015 5:40:00 PM | Browse: 1038 | Download: 1707
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Received |
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2015-03-12 09:13 |
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Peer-Review Started |
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2015-03-12 19:09 |
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To Make the First Decision |
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2015-04-10 17:44 |
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Return for Revision |
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2015-04-17 09:15 |
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Revised |
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2015-05-09 18:01 |
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Second Decision |
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2015-05-29 15:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-06-08 16:05 |
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Articles in Press |
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2015-06-08 16:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-06-09 16:13 |
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Publish the Manuscript Online |
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2015-06-29 17:40 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Randomized Clinical Trial |
| Article Title |
1H nuclear magnetic resonance spectroscopy-based metabonomic study in patients with cirrhosis and hepatic encephalopathy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Konstantinos John Dabos, John Andrew Parkinson, Ian Howard Sadler, John Nicholas Plevris and Peter Clive Hayes |
| Funding Agency and Grant Number |
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| Corresponding Author |
Konstantinos John Dabos, MD, PhD, Centre of Liver and Digestive Disorders, Royal Infirmary of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SA, Scotland,
United Kingdom. konstantinos.dabos@nhslothian.scot.nhs.uk
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| Key Words |
Ketone bodies; Branch chain amino acids; Glutamine; Glycolysis |
| Core Tip |
Few studies have approached the metabolic abnormalities of liver cirrhosis and its complication hepatic encephalopathy. This study provides evidence that in stable cirrhosis key metabolic pathways are impaired and confirms the fact that there is impaired gluconeogensis, impaired ketogensis and ketone bodies break down as well as impaired urea cycle. In encephalopathy there is a reversal in the pattern of branch chain amino acids concentrations towards normal. By using stepwise discriminating analysis we were able to separate with remarkable accuracy metabolic phenotypes of cirrhotic patients from controls and also those who suffered from encephalopathy from those cirrhotics who did not.
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| Publish Date |
2015-06-29 17:40 |
| Citation |
Dabos KJ, Parkinson JA, Sadler IH, Plevris JN, Hayes PC. 1H nuclear magnetic resonance spectroscopy-based metabonomic study in patients with cirrhosis and hepatic encephalopathy. World J Hepatol 2015; 7(12): 1701-1707 |
| URL |
http://www.wjgnet.com/1948-5182/full/v7/i12/1701.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v7.i12.1701 |
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