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6/29/2015 5:40:00 PM | Browse: 442 | Download: 529
Publication Name World Journal of Hepatology
Manuscript ID 17546
Country/Territory United Kingdom
2015-03-12 09:13
Peer-Review Started
2015-03-12 19:09
To Make the First Decision
2015-04-10 17:44
Return for Revision
2015-04-17 09:15
2015-05-09 18:01
Second Decision
2015-05-29 15:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-06-08 16:05
Articles in Press
2015-06-08 16:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-09 16:13
Publish the Manuscript Online
2015-06-29 17:40
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Randomized Clinical Trial
Article Title 1H nuclear magnetic resonance spectroscopy-based metabonomic study in patients with cirrhosis and hepatic encephalopathy
Manuscript Source Invited Manuscript
All Author List Konstantinos John Dabos, John Andrew Parkinson, Ian Howard Sadler, John Nicholas Plevris and Peter Clive Hayes
Funding Agency and Grant Number
Corresponding author Konstantinos John Dabos, MD, PhD, Centre of Liver and Digestive Disorders, Royal Infirmary of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SA, Scotland, United Kingdom. konstantinos.dabos@nhslothian.scot.nhs.uk
Keywords Ketone bodies; Branch chain amino acids; Glutamine; Glycolysis
Core Tip Few studies have approached the metabolic abnormalities of liver cirrhosis and its complication hepatic encephalopathy. This study provides evidence that in stable cirrhosis key metabolic pathways are impaired and confirms the fact that there is impaired gluconeogensis, impaired ketogensis and ketone bodies break down as well as impaired urea cycle. In encephalopathy there is a reversal in the pattern of branch chain amino acids concentrations towards normal. By using stepwise discriminating analysis we were able to separate with remarkable accuracy metabolic phenotypes of cirrhotic patients from controls and also those who suffered from encephalopathy from those cirrhotics who did not.
Publish Date 2015-06-29 17:40
Citation Dabos KJ, Parkinson JA, Sadler IH, Plevris JN, Hayes PC. 1H nuclear magnetic resonance spectroscopy-based metabonomic study in patients with cirrhosis and hepatic encephalopathy. World J Hepatol 2015; 7(12): 1701-1707
Url http://www.wjgnet.com/1948-5182/full/v7/i12/1701.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i12.1701
Full Article (PDF) WJH-7-1701.pdf
Full Article (Word) WJH-7-1701.doc
Manuscript File 17546-Review.doc
Answering Reviewers 17546-Answering reviewers.pdf
Audio Core Tip 17546-Audio core tip.wma
Biostatistics Review Certificate 17546-Biostatistics statement.pdf
Clinical Trial Registration Statement 17546-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 17546-Conflict-of-interest statement.pdf
Copyright License Agreement 17546-Copyright assignment.pdf
Data Sharing Statement 17546-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) 17546-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document 17546-Institutional review board statement.pdf
Peer-review Report 17546-Peer-review(s).pdf
Scientific Misconduct Check 17546-Scientific misconduct check.pdf
Scientific Editor Work List 17546-Scientific editor work list.pdf