BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/24/2015 3:55:00 PM | Browse: 1038 | Download: 2429
 |
Received |
|
2015-03-12 18:06 |
|
Peer-Review Started |
|
2015-03-13 13:37 |
|
To Make the First Decision |
|
2015-06-02 15:31 |
|
Return for Revision |
|
2015-06-07 17:53 |
|
Revised |
|
2015-06-19 20:46 |
|
Second Decision |
|
2015-07-27 20:13 |
|
Accepted by Journal Editor-in-Chief |
|
2015-07-27 21:29 |
|
Accepted by Executive Editor-in-Chief |
|
2015-08-25 18:12 |
|
Articles in Press |
|
2015-08-25 18:12 |
 |
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
2015-09-25 07:32 |
|
Typeset the Manuscript |
|
2015-10-27 09:34 |
|
Publish the Manuscript Online |
|
2015-11-18 12:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
|
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Retinoic acid receptor α promotes autophagy to alleviate liver ischemia and reperfusion injury
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chen Zhong, Li-Yong Pu, Ming-Ming Fang, Zhen Gu, Jian-Hua Rao and Xue-Hao Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81273261 |
|
| Corresponding Author |
Xue-Hao Wang, MD, PhD, Key Laboratory of Living Donor Liver Transplantation of Chinese Ministry of Health, Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. wangxh@njmu.edu.cn
|
| Key Words |
Ischemia/reperfusion; Retinoic acid receptor α; Foxo3a; Foxo1; Autophagy |
| Core Tip |
To investigate the role of autophagy and the relationship between all-trans retinoic acid (ATRA) and autophagy in liver ischemia and reperfusion (IR) injury. We found that ATRA pretreatment alleviated liver IR injury by inducing autophagy and it may involves retinoic acid receptor α (RARα) activity. To clarify the mechanism of RARα, we used LE540 to inhibit RARα during reactive oxygen species-inducing cell damage in vitro. Our data showed that RARα activation enhanced Foxo3a and p-Akt expression except Foxo1. The Foxo3a/p-Akt/Foxo1 pathway has previously been proven to promote autophagy. Hence, we conclude that ATRA activates RARα to reduce liver IR injury by regulating the Foxo3a/p-Akt/Foxo1 pathway to promote autophagy.
|
| Publish Date |
2015-11-18 12:39 |
| Citation |
Zhong C, Pu LY, Fang MM, Gu Z, Rao JH, Wang XH. Retinoic acid receptor α promotes autophagy to alleviate liver ischemia and reperfusion injury. World J Gastroenterol 2015; 21(43): 12381-12391 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i43/12381.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i43.12381 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
