Publication Name	World Journal of Gastroenterology
Manuscript ID	17574
Country	United States

Received	2015-03-13 08:43
Peer-Review Started	2015-03-14 13:05
To Make the First Decision	2015-04-23 13:14
Return for Revision	2015-04-30 16:22
Revised	2015-05-13 08:18
Second Decision	2015-06-12 07:48
Accepted by Journal Editor-in-Chief	2015-06-12 21:14
Accepted by Executive Editor-in-Chief	2015-06-26 15:11
Articles in Press	2015-06-26 15:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-01 18:56
Publish the Manuscript Online	2015-08-17 11:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Calcium glycerophosphate preserves transepithelial integrity in the caco-2 model of intestinal transport
Manuscript Source	Unsolicited Manuscript
All Author List	Palika Datta and Margaret T Weis
Funding Agency and Grant Number	Funding Agency Grant Number AKPharma Corporation, MW
Corresponding Author	Margaret T Weis, PhD, Associate Professor, Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106, United States. margaret.weis@ttuhsc.edu
Key Words	Calcium glycerophosphate; Gliadin peptide; Intestinal permeability; Intestinal ischemia; Cytokine
Core Tip	This article presents a novel role for calcium glycerophosphate in preserving the gut epithelial integrity during hypoxia and in the presence of cytokines. Calcium glycerophosphate showed a significant time and concentration dependent effect to attenuate increased gut permeability caused by hypoxia, cytokine stimulation and α-gliadin peptide 31-55. The effect was observable even at concentrations as low as 1 μmol/L. A better understanding of this phenomenon would help in devising new preventive and therapeutic regimens.
Publish Date	2015-08-17 11:15
Citation	Datta P, Weis MT. Calcium glycerophosphate preserves transepithelial integrity in the caco-2 model of intestinal transport. World J Gastroenterol 2015; 21(30): 9055-9066
URL	http://www.wjgnet.com/1007-9327/full/v21/i30/9055.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i30.9055

Full Article (PDF)	WJG-21-9055.pdf
Full Article (Word)	WJG-21-9055.doc
Manuscript File	17574-Review.docx
Answering Reviewers	17574-Answering reviewers.pdf
Audio Core Tip	17574-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17574-Conflict-of-interest statement.pdf
Copyright License Agreement	17574-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	17574-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	17574-Institutional review board statement.pdf
Peer-review Report	17574-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17574-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17574-Scientific misconduct check.pdf
Scientific Editor Work List	17574-Scientific editor work list.docx.pdf