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Articles Published Processes
9/14/2015 4:53:00 PM | Browse: 1560 | Download: 2366
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Received |
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2015-03-20 17:46 |
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Peer-Review Started |
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2015-03-21 16:23 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2015-04-20 16:41 |
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Revised |
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2015-05-16 15:46 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2015-07-07 22:30 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2015-07-08 17:56 |
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Articles in Press |
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2015-07-08 17:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-08-18 17:00 |
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Publish the Manuscript Online |
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2015-09-14 16:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dexamethasone inhibits hypoxia-induced epithelial-mesenchymal transition in colon cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jung Ho Kim, You-Jin Hwang, Sang Hoon Han, Young Eun Lee, Saerom Kim, Yoon Jae Kim, Jae Hee Cho, Kwang An Kwon, Ju Hyun Kim and Se-Hee Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Korea Health Technology R&D Project |
HI13C-1602-010014 |
| Gachon University Gil Medical Center |
2013-01 |
| Gachon University Gil Medical Center |
2014-11 |
| Gachon University Gil Medical Center |
2014-25 |
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| Corresponding Author |
Se-Hee Kim, PhD, Gachon Medical Research Institute, Gachon University Gil Medical Center, 21 Namdong-daero 774 beon-gil, Namdong-gu, Incheon 405-760, South Korea. sehee0423@gilhospital.com |
| Key Words |
Dexamethasone; Colon cancer; Hypoxia; Hypoxia-inducible factor-1α; Epithelial-mesenchymal transition |
| Core Tip |
In solid tumors, the heightened metabolism of cancer cells often leads to areas of hypoxia that can drive epithelial-mesenchymal transition (EMT). Dexamethasone is often given to patients with colon cancer to limit the negative side effects of chemotherapy. Our study investigated the effects of dexamethasone on hypoxia-induced EMT and found that it was sufficient to block the propensity for cells to undergo EMT by repressing the hypoxia-induced expression of Hypoxia-inducible factor-1α, vascular endothelial growth factor and other EMT markers. This evidence suggests that dexamethasone co-treatment may limit the migratory properties of colorectal cancer cells that subsist in the hypoxic regions of colorectal cancers. |
| Publish Date |
2015-09-14 16:54 |
| Citation |
Kim JH, Hwang YJ, Han SH, Lee YE, Kim S, Kim YJ, Cho JH, Kwon KA, Kim JH, Kim SH. Dexamethasone inhibits hypoxia-induced epithelial-mesenchymal transition in colon cancer. World J Gastroenterol 2015; 21(34): 9887-9899
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| URL |
http://www.wjgnet.com/1007-9327/full/v21/i34/9887.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i34.9887 |
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