Publication Name	World Journal of Gastroenterology
Manuscript ID	1783
Country	China

Received	2013-01-06 08:50
Peer-Review Started	2013-01-06 11:36
To Make the First Decision	2013-02-01 21:45
Return for Revision	2013-02-03 18:22
Revised	2013-03-04 19:54
Second Decision	2013-04-09 20:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-04-10 07:39
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-13 19:22
Publish the Manuscript Online	2013-06-04 12:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins
Manuscript Source	Invited Manuscript
All Author List	Yu-Gang Wang, Na Wang, Guang-Ming Li, Wen-Li Fang, Jue Wei, Jia-Li Ma, Ting Wang and Min Shi
Funding Agency and Grant Number	Funding Agency Grant Number Shanghai Municipal Health Bureau Key Disciplines ZK2012A05 National Natural Science Foundation 81070344
Corresponding Author	Min Shi, MD, PhD, Department of Gastroenterology, Shanghai Changning Central Hospital, No. 1111 Xianxia Road, Changning district, Shanghai 200336, China. shimingdyx@yeah.net
Key Words	Trichostatin A; Acetylation modification; Gastric cancer; Mass spectrometry; ATP5O; PKM2
Core Tip	Previous research has shown that deacetyltransferase inhibitors not only induce cell cycle arrest, differentiation and apoptosis of many tumor cells in vitro, but also inhibit tumor growth in tumor-bearing animals. They are through the acetylation modification of deacetyltransferase inhibitor on histone. Only a few studies have focused on the acetylation modification by deacetyltransferase on non-histone. This is the first study to identify acetylated proteins in gastric cancer cells before and after exposure to trichostatin A to explore the effect of lysine acetylation of related proteins on the regulation of gastric cancer cell proliferation. Moreover, the lysine-acetylated proteins and the modified sites in AGS cells were assessed. We explored whether ATP5O was obviously acetylated after trichostatin A treatment in AGS cells.
Publish Date	2013-06-04 12:34
Citation	Wang YG, Wang N, Li GM, Fang WL, Wei J, Ma JL, Wang T, Shi M. Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins. World J Gastroenterol 2013; 19(21): 3226-3240
URL	http://www.wjgnet.com/1007-9327/full/v19/i21/3226.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i21.3226

Full Article (PDF)	WJG-19-3226.pdf
Manuscript File	1783-Review.doc
Answering Reviewers	1783-Answering reviewers.doc
Copyright License Agreement	1783-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	1783-Language certificate.doc
Peer-review Report	1783-Peer review(s).pdf
Scientific Editor Work List	1783-Scientific editor work list.doc