Publication Name	World Journal of Gastroenterology
Manuscript ID	17939
Country	United States

Received	2015-03-31 08:06
Peer-Review Started	2015-03-31 10:28
To Make the First Decision	2015-04-23 13:14
Return for Revision	2015-04-30 16:50
Revised	2015-05-02 03:11
Second Decision	2015-05-20 07:51
Accepted by Journal Editor-in-Chief	2015-05-22 04:13
Accepted by Executive Editor-in-Chief	2015-05-27 19:55
Articles in Press	2015-05-27 19:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-27 15:53
Publish the Manuscript Online	2015-07-22 13:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Michael Bordonaro and Darina L Lazarova
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health (Bethesda, MD) National Cancer Institute 1R15CA149589-01
Corresponding Author	Michael Bordonaro, PhD, Associate Professor of Molecular Biology, Department of Basic Sciences, The Commonwealth Medical College, 525 Pine Street, Scranton, PA 18509, United States. mbordonaro@tcmedc.org
Key Words	CREB-binding protein; p300; Wnt; Colorectal cancer; Butyrate; Stem cells
Core Tip	Deregulated Wnt/?-catenin signaling is responsible for initiating most human colorectal cancer (CRC), and hyperactivation of this pathway by histone deacetylase inhibitors such as butyrate, derived from dietary fiber, promotes CRC cell death. The transcriptional cofactors CREB-binding protein (CBP) or p300 affect Wnt signaling and the hyperactivation of this pathway by butyrate. CBP and p300 likely affect colonic tumorigenesis, stem cell fate, and butyrate resistance in CRC. Therefore, pharmacological or genetic methodologies that target CBP- and p300-mediated Wnt activity are possible preventive or therapeutic approaches against CRC.
Publish Date	2015-07-22 13:58
Citation	Bordonaro M, Lazarova DL. CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer. World J Gastroenterol 2015; 21(27): 8238-8248
URL	http://www.wjgnet.com/1007-9327/full/v21/i27/8238.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i27.8238

Full Article (PDF)	WJG-21-8238.pdf
Full Article (Word)	WJG-21-8238.doc
Manuscript File	17939-Review.docx
Answering Reviewers	17939-Answering reviewers.pdf
Audio Core Tip	17939-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17939-Conflict-of-interest statement.pdf
Copyright License Agreement	17939-Copyright assignment.pdf
Peer-review Report	17939-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17939-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17939-Scientific misconduct check.pdf
Scientific Editor Work List	17939-Scientific editor work list.pdf