BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
7/22/2015 2:02:00 PM | Browse: 980 | Download: 1403
Publication Name World Journal of Gastroenterology
Manuscript ID 17939
Country/Territory United States
Received
2015-03-31 08:06
Peer-Review Started
2015-03-31 10:28
To Make the First Decision
2015-04-23 13:14
Return for Revision
2015-04-30 16:50
Revised
2015-05-02 03:11
Second Decision
2015-05-20 07:51
Accepted by Journal Editor-in-Chief
2015-05-22 04:13
Accepted by Company Editor-in-Chief
2015-05-27 19:55
Articles in Press
2015-05-27 19:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-27 15:53
Publish the Manuscript Online
2015-07-22 13:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Topic Highlights
Article Title CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer
Manuscript Source Invited Manuscript
All Author List Michael Bordonaro and Darina L Lazarova
Funding Agency and Grant Number
Funding Agency Grant Number
National Institutes of Health (Bethesda, MD) National Cancer Institute 1R15CA149589-01
Corresponding Author Michael Bordonaro, PhD, Associate Professor of Molecular Biology, Department of Basic Sciences, The Commonwealth Medical College, 525 Pine Street, Scranton, PA 18509, United States. mbordonaro@tcmedc.org
Key Words CREB-binding protein; p300; Wnt; Colorectal cancer; Butyrate; Stem cells
Core Tip Deregulated Wnt/?-catenin signaling is responsible for initiating most human colorectal cancer (CRC), and hyperactivation of this pathway by histone deacetylase inhibitors such as butyrate, derived from dietary fiber, promotes CRC cell death. The transcriptional cofactors CREB-binding protein (CBP) or p300 affect Wnt signaling and the hyperactivation of this pathway by butyrate. CBP and p300 likely affect colonic tumorigenesis, stem cell fate, and butyrate resistance in CRC. Therefore, pharmacological or genetic methodologies that target CBP- and p300-mediated Wnt activity are possible preventive or therapeutic approaches against CRC.
Publish Date 2015-07-22 13:58
Citation Bordonaro M, Lazarova DL. CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer. World J Gastroenterol 2015; 21(27): 8238-8248
URL http://www.wjgnet.com/1007-9327/full/v21/i27/8238.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i27.8238
Full Article (PDF) WJG-21-8238.pdf
Full Article (Word) WJG-21-8238.doc
Manuscript File 17939-Review.docx
Answering Reviewers 17939-Answering reviewers.pdf
Audio Core Tip 17939-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 17939-Conflict-of-interest statement.pdf
Copyright License Agreement 17939-Copyright assignment.pdf
Peer-review Report 17939-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 17939-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 17939-Scientific misconduct check.pdf
Scientific Editor Work List 17939-Scientific editor work list.pdf