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Articles Published Processes
11/24/2015 3:55:00 PM | Browse: 1224 | Download: 2174
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Received |
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2015-03-31 07:56 |
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Peer-Review Started |
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2015-03-31 11:51 |
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To Make the First Decision |
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2015-05-18 12:10 |
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Return for Revision |
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2015-05-20 10:59 |
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Revised |
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2015-06-02 02:05 |
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Second Decision |
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2015-07-03 20:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-07-08 17:27 |
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Articles in Press |
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2015-07-08 17:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-10-27 14:04 |
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Publish the Manuscript Online |
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2015-11-18 12:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Re-re-treatment of hepatitis C virus: Eight patients who relapsed twice after direct-acting-antiviral drugs
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Joshua Hartman, Kian Bichoupan, Neal Patel, Sweta Chekuri, Alyson Harty, Douglas Dieterich, Ponni Perumalswami and Andrea D Branch |
| Funding Agency and Grant Number |
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| Corresponding Author |
Andrea D Branch, PhD, Division of Liver Disease, Icahn School of Medicine at the Mount Sinai Medical Center, 11th floor, Room 24, 1425 Madison Avenue, New York, NY 10029, United States. andrea.branch@mssm.edu |
| Key Words |
Hepatitis C; Protease inhibitor; Relapse; Simeprevir; Sofosbuvir; Treatment failure |
| Core Tip |
Direct acting antivirals are revolutionizing the treatment of chronic hepatitis C (HCV) infection, but are also increasing the number of patients who have failed multiple rounds of treatment. Information about these patients is needed to plan salvage treatment strategies. We present eight patients who failed treatment with the first generation protease inhibitors and subsequently failed treatment with simeprevir and sofosbuvir. Their shared characteristics include a history of failed treatment with interferon/ribavirin and liver cirrhosis. Seven had genotype 1a HCV and a high viral load. Our findings suggest that patients with cirrhosis and high viral load remain hard-to-treat.
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| Publish Date |
2015-11-18 12:39 |
| Citation |
Hartman J, Bichoupan K, Patel N, Chekuri S, Harty A, Dieterich D, Perumalswami P, Branch AD. Re-re-treatment of hepatitis C virus: Eight patients who relapsed twice after direct-acting-antiviral drugs. World J Gastroenterol 2015; 21(43): 12430-12438 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i43/12430.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i43.12430 |
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