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Articles Published Processes
9/14/2015 4:53:00 PM | Browse: 1020 | Download: 1532
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Received |
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2015-04-06 15:56 |
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Peer-Review Started |
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2015-04-07 10:58 |
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To Make the First Decision |
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2015-05-18 12:17 |
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Return for Revision |
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2015-05-22 10:43 |
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Revised |
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2015-06-03 13:47 |
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Second Decision |
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2015-07-03 21:03 |
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Accepted by Journal Editor-in-Chief |
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2015-07-06 09:07 |
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Accepted by Executive Editor-in-Chief |
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2015-07-08 17:42 |
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Articles in Press |
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2015-07-08 17:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-08-19 16:20 |
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Publish the Manuscript Online |
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2015-09-14 16:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
PNPLA3 I148M variant affects non-alcoholic fatty liver disease in liver transplant recipients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zheng-Tao Liu, Tian-Chi Chen, Xiao-Xiao Lu, Jun Cheng, Hai-Yang Xie, Lin Zhou and Shu-Sen Zheng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science and Technology Major Project of China |
2012ZX10002017 |
| Science Fund for Creative Research Groups of the National Natural Science Foundation of China |
81421062 |
| China Postdoctoral Science Foundation |
2015M570518 |
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| Corresponding Author |
Shu-Sen Zheng, Professor, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou 310003, Zhejiang Province, China. shusenzheng@zju.edu.cn |
| Key Words |
PNPLA3; TM6SF2; Non-alcoholic fatty liver disease; Liver transplantation; Recipient |
| Core Tip |
Previous genomic studies identified PNPLA3 I148M and TM6SF2 E167K polymorphisms as the most prominent genetic variations associated with non-alcoholic fatty liver disease (NAFLD) susceptibility in general populations. However, these impacts have never been evaluated in long-term liver transplant recipients. In a collection of survivors 10 years after liver transplantation, we found that the PNPLA3 I148M, but not TM6SF2 E167K polymorphism, affected de novo NAFLD predisposition and interacted with obesity. Our results revealed that liver transplant recipients might benefit from weight control to limit the deleterious effect exerted by genetic factors. |
| Publish Date |
2015-09-14 16:54 |
| Citation |
Liu ZT, Chen TC, Lu XX, Cheng J, Xie HY, Zhou L, Zheng SS. PNPLA3 I148M variant affects non-alcoholic fatty liver disease in liver transplant recipients. World J Gastroenterol 2015; 21(34): 10054-10056 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i34/10054.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i34.10054 |
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