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Articles Published Processes
7/10/2015 5:56:00 PM | Browse: 1058 | Download: 1717
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Received |
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2015-04-11 10:52 |
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Peer-Review Started |
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2015-04-13 08:12 |
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To Make the First Decision |
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2015-05-14 16:45 |
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Return for Revision |
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2015-05-19 09:24 |
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Revised |
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2015-05-21 23:08 |
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Second Decision |
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2015-06-12 08:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-06-19 17:44 |
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Articles in Press |
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2015-06-19 17:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-06-25 11:02 |
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Publish the Manuscript Online |
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2015-07-10 17:51 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Minireviews |
| Article Title |
Drug- and herb-induced liver injury: Progress, current challenges and emerging signals of post-marketing risk
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Emanuel Raschi and Fabrizio De Ponti |
| Funding Agency and Grant Number |
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| Corresponding Author |
Fabrizio De Ponti, MD, PhD, Pharmacology Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Via Irnerio, 48, I-40126 Bologna, Italy. fabrizio.deponti@unibo.it
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| Key Words |
Hepatotoxicity; Liver damage; Herb; Signal; Safety; Predictivity |
| Core Tip |
Drug- and herb-induced liver injury remains a clinical challenge, attracting multidisciplinary interest
for its translational aspects (from bench to bedside approach and vice versa). When considering differential diagnosis in patients with liver damage, clinicians should always keep in mind drugs and herbs as possible liver offenders, especially in subjects with comorbidities requiring long-term multiple therapies (likelihood of drug interactions). Drug withdrawal and therapy reconciliation represent key issues in patient’ management to minimize the risk of acute liver failure. Notwithstanding the progress in the tools for early detection of hepatotoxicity, there is growing literature on drugs and herbs possibly associated with liver injury in the post-marketing phase: often undetected during drug development, signals of liver toxicity emerge from spontaneous reporting systems and registries. This calls for a joint, multi-disciplinary action to improve predictivity of pre-clinical assays, continuing post-marketing surveillance and designing ad hoc population-based studies.
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| Publish Date |
2015-07-10 17:51 |
| Citation |
Raschi E, De Ponti F. Drug- and herb-induced liver injury: Progress, current challenges and emerging signals of post-marketing risk. World J Hepatol 2015; 7(13): 1761-1771 |
| URL |
http://www.wjgnet.com/1948-5182/full/v7/i13/1761.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v7.i13.1761 |
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