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Articles Published Processes
12/6/2015 1:18:00 PM | Browse: 1292 | Download: 2052
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Received |
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2015-04-16 16:46 |
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Peer-Review Started |
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2015-04-18 16:21 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2015-06-20 17:32 |
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Revised |
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2015-07-02 23:37 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2015-08-19 14:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2015-09-02 15:29 |
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Articles in Press |
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2015-09-02 15:29 |
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Edit the Manuscript by Language Editor |
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2015-10-06 09:04 |
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Typeset the Manuscript |
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2015-11-23 18:12 |
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Publish the Manuscript Online |
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2015-12-06 13:18 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Heat shock pretreatment improves stem cell repair following ischemia-reperfusion injury via autophagy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Fei Qiao, Lei Yao, Xin-Chen Zhang, Guo-Dong Li and De-Quan Wu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Clinical Research Special Fund of Wu Jieping Medical Foundation |
320.6750.12263 |
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| Corresponding Author |
De-Quan Wu, PhD, Professor, Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Nangang District, Harbin 150001, Heilongjiang Province, China. wudequanhmu@163.com |
| Key Words |
Hepatic ischemia-reperfusion injury; Heat shock pretreatment; Mesenchymal stem cells; Autophagy; Transplantation |
| Core Tip |
We investigated the interaction between autophagy and apoptosis in mesenchymal stem cells (MSCs) exposed to H2O2. We found that heat shock pretreatment (HSP)-induced autophagy served as a protective mechanism. HSP for 2 h improved the therapeutic potential of MSCs in the treatment of ischemia-reperfusion (I/R) injury in rats and enhanced autophagy via the p38MAPK/mTOR pathway, which is involved in the protective effects of HSP on H2O2-induced MSC apoptosis. Systemic administration led to an increase in HSP-MSCs homing to I/R liver cells compared with MSCs, resulting in a significant improvement in liver function, accelerated mitogenic response and alleviation of histopathological damage.
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| Publish Date |
2015-12-06 13:18 |
| Citation |
Qiao PF, Yao L, Zhang XC, Li GD, Wu DQ. Heat shock pretreatment improves stem cell repair following ischemia-reperfusion injury via autophagy. World J Gastroenterol 2015; 21(45): 12822-12834 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i45/12822.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i45.12822 |
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