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Articles Published Processes
11/12/2015 7:10:00 PM | Browse: 1174 | Download: 1939
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Received |
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2015-04-21 09:45 |
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Peer-Review Started |
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2015-04-21 11:37 |
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To Make the First Decision |
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2015-06-25 17:54 |
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Return for Revision |
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2015-07-01 10:13 |
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Revised |
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2015-07-16 03:27 |
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Second Decision |
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2015-08-07 17:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-08-14 16:24 |
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Articles in Press |
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2015-08-14 16:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-10-16 13:58 |
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Publish the Manuscript Online |
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2015-11-12 18:51 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kunwar Shailubhai, Vaseem Palejwala, Krishna Priya Arjunan, Sayali Saykhedkar, Bradley Nefsky, John A Foss, Stephen Comiskey, Gary S Jacob and Scott E Plevy |
| Funding Agency and Grant Number |
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| Corresponding Author |
Kunwar Shailubhai, Doctor of Philosophy, Chief Scientific Officer, R and D Center, Synergy Pharmaceuticals Inc., 3805 Old Easton Road, Doylestown, PA 18902, United States. shailu@synergypharma.com |
| Key Words |
Guanylate cyclase-C; Uroguanylin; Plecanatide; Dolcanatide; Inflammatory bowel disease |
| Core Tip |
Plecanatide (SP-304) and dolcanatide (SP-333) are structurally close analogs of the human endogenous natriuretic peptide uroguanylin, a ligand of guanylate cyclase-C (GC-C). Here we report that oral treatment with plecanatide or dolcanatide effectively ameliorates colitis in acute and chronic models of murine experimental colitis. The anti-inflammatory activity of plecanatide and dolcanatide was comparable to that achieved after treatment with sulfasalazine or 5-amino salicylic acid. This is the first-ever study reporting the therapeutic utility of GC-C agonists as a new class of orally delivered and mucosally active drug candidates for the treatment and management of inflammatory bowel diseases in humans. |
| Publish Date |
2015-11-12 18:51 |
| Citation |
Shailubhai K, Palejwala V, Arjunan KP, Saykhedkar S, Nefsky B, Foss JA, Comiskey S, Jacob GS, Plevy SE. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther 2015; 6(4): 213-222 |
| URL |
http://www.wjgnet.com/2150-5349/full/v6/i4/213.htm |
| DOI |
http://dx.doi.org/10.4292/wjgpt.v6.i4.213 |
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