Publication Name	World Journal of Gastroenterology
Manuscript ID	18455
Country	United States

Received	2015-04-21 08:47
Peer-Review Started	2015-04-21 19:49
To Make the First Decision	2015-05-18 12:21
Return for Revision	2015-05-22 11:09
Revised	2015-06-16 07:12
Second Decision	2015-07-27 20:19
Accepted by Journal Editor-in-Chief	2015-07-28 04:18
Accepted by Company Editor-in-Chief	2015-08-25 18:47
Articles in Press	2015-08-25 18:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-31 16:49
Publish the Manuscript Online	2015-10-23 15:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Genetic epidemiology of irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Jasbir Makker, Sridhar Chilimuri and Jonathan N Bella
Funding Agency and Grant Number
Corresponding Author	Jonathan N Bella, MD, Department of Medicine, Bronx-Lebanon Hospital Center and Albert Einstein College of Medicine, 12th Floor, 1650 Grand Concourse, Bronx, NY 10457, United States. jonnbella@earthlink.net
Key Words	Irritable bowel syndrome; Single-nucleotide polymorphism; Serotonin; Familial aggregation; Genetics
Core Tip	Irritable bowel syndrome (IBS) is believed to result from interplay of several factors including hypersensitivity of the bowel, altered bowel motility, inflammation and stress. Familial aggregation of cases and twin studies underscore the genetic basis of IBS. Different researchers have studied several candidate genes but the evidence so far linking IBS to specific genes is inconsistent and weak. Genome wide association studies that can examine several common genetic variants are needed to design newer drugs and diagnostic methods.
Publish Date	2015-10-23 15:45
Citation	Makker J, Chilimuri S, Bella JN. Genetic epidemiology of irritable bowel syndrome. World J Gastroenterol 2015; 21(40): 11353-11361
URL	http://www.wjgnet.com/1007-9327/full/v21/i40/11353.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i40.11353

Full Article (PDF)	WJG-21-11353.pdf
Full Article (Word)	WJG-21-11353.doc
Manuscript File	18455-Review.docx
Answering Reviewers	18455-Answering reviewers.pdf
Audio Core Tip	18455-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	18455-Conflict-of-interest statement.pdf
Copyright License Agreement	18455-Copyright assignment.pdf
Peer-review Report	18455-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18455-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18455-Scientific misconduct check.pdf
Scientific Editor Work List	18455-Scientific editor work list.pdf