Publication Name	World Journal of Gastroenterology
Manuscript ID	18726
Country	Norway

Received	2015-04-27 10:14
Peer-Review Started	2015-04-30 12:09
To Make the First Decision	2015-06-23 14:52
Return for Revision	2015-06-26 14:15
Revised	2015-07-07 05:21
Second Decision	2015-09-13 22:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-15 13:29
Articles in Press	2015-09-15 13:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-21 13:58
Publish the Manuscript Online	2015-11-03 17:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pathology
Manuscript Type	Topic Highlights
Article Title	Neuroendocrine differentiation: The mysterious fellow of colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Britta Kleist and Micaela Poetsch
Funding Agency and Grant Number
Corresponding Author	Britta Kleist, MD, PhD, Department of Pathology, Southern Hospital Trust, Postbox 416, 4604 Kristiansand, Norway. britta.kleist@sshf.no
Key Words	Neuroendocrine differentiation; Colorectal cancer; mTOR pathway; Neuroendocrine tumorigenesis; Targeted therapy
Core Tip	Neuroendocrine differentiation in sporadic colorectal cancer has been recognized since deca?des. In contrast to the clinico-pathologically well-defined pure neuroendocrine tumors and mixed adenoneuroendocrine carcinomas of the colon and rectum, the clinical impact of focal neuroendocrine differentiation in colorectal carcinomas is still con?troversially discussed. Further insights into the regulation of neuroendocrine differentiation by mTOR pathway components and recent knowledge about a link of enteroendocrine cells to the intestinal stem cell compartment hint at a role of neuroendocrine cells as prognostic marker and putative therapeutic target in sporadic colorectal cancer.
Publish Date	2015-11-03 17:31
Citation	Kleist B, Poetsch M. Neuroendocrine differentiation: The mysterious fellow of colorectal cancer. World J Gastroenterol 2015; 21(41): 11740-11747
URL	http://www.wjgnet.com/1007-9327/full/v21/i41/11740.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i41.11740

Full Article (PDF)	WJG-21-11740.pdf
Full Article (Word)	WJG-21-11740.doc
Manuscript File	18726-Review.docx
Answering Reviewers	18726-Answering reviewers.pdf
Audio Core Tip	18726-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18726-Conflict-of-interest statement.pdf
Copyright License Agreement	18726-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18726-Language certificate.docx
Peer-review Report	18726-Peer-review(s).pdf
Scientific Misconduct Check	18726-Scientific misconduct check.pdf
Scientific Editor Work List	18726-Scientific editor work list.pdf