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11/3/2015 5:30:00 PM | Browse: 503 | Download: 639
Publication Name World Journal of Gastroenterology
Manuscript ID 18726
Country/Territory Norway
Received
2015-04-27 10:14
Peer-Review Started
2015-04-30 12:09
To Make the First Decision
2015-06-23 14:52
Return for Revision
2015-06-26 14:15
Revised
2015-07-07 05:21
Second Decision
2015-09-13 22:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-09-15 13:29
Articles in Press
2015-09-15 13:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-21 13:58
Publish the Manuscript Online
2015-11-03 17:31
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pathology
Manuscript Type Topic Highlights
Article Title Neuroendocrine differentiation: The mysterious fellow of colorectal cancer
Manuscript Source Invited Manuscript
All Author List Britta Kleist and Micaela Poetsch
Funding Agency and Grant Number
Corresponding author Britta Kleist, MD, PhD, Department of Pathology, Southern Hospital Trust, Postbox 416, 4604 Kristiansand, Norway. britta.kleist@sshf.no
Keywords Neuroendocrine differentiation; Colorectal cancer; mTOR pathway; Neuroendocrine tumorigenesis; Targeted therapy
Core Tip Neuroendocrine differentiation in sporadic colorectal cancer has been recognized since deca?des. In contrast to the clinico-pathologically well-defined pure neuroendocrine tumors and mixed adenoneuroendocrine carcinomas of the colon and rectum, the clinical impact of focal neuroendocrine differentiation in colorectal carcinomas is still con?troversially discussed. Further insights into the regulation of neuroendocrine differentiation by mTOR pathway components and recent knowledge about a link of enteroendocrine cells to the intestinal stem cell compartment hint at a role of neuroendocrine cells as prognostic marker and putative therapeutic target in sporadic colorectal cancer.
Publish Date 2015-11-03 17:31
Citation Kleist B, Poetsch M. Neuroendocrine differentiation: The mysterious fellow of colorectal cancer. World J Gastroenterol 2015; 21(41): 11740-11747
Url http://www.wjgnet.com/1007-9327/full/v21/i41/11740.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i41.11740
Full Article (PDF) WJG-21-11740.pdf
Full Article (Word) WJG-21-11740.doc
Manuscript File 18726-Review.docx
Answering Reviewers 18726-Answering reviewers.pdf
Audio Core Tip 18726-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 18726-Conflict-of-interest statement.pdf
Copyright License Agreement 18726-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 18726-Language certificate.docx
Peer-review Report 18726-Peer-review(s).pdf
Scientific Misconduct Check 18726-Scientific misconduct check.pdf
Scientific Editor Work List 18726-Scientific editor work list.pdf