Publication Name	World Journal of Hepatology
Manuscript ID	18742
Country	China

Received	2015-04-27 10:06
Peer-Review Started	2015-04-30 17:54
To Make the First Decision	2015-07-17 17:53
Return for Revision	2015-07-25 15:50
Revised	2015-08-10 18:09
Second Decision	2015-08-19 14:47
Accepted by Journal Editor-in-Chief	2015-08-19 16:11
Accepted by Executive Editor-in-Chief	2015-08-21 16:08
Articles in Press	2015-08-21 16:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-26 08:51
Publish the Manuscript Online	2015-08-29 17:10

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Strategies to increase the resectability of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Wong Hoi She and Kenneth SH Chok
Funding Agency and Grant Number
Corresponding Author	Dr. Kenneth SH Chok, MBBS, Depart­ment of Surgery, the University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, China. kennethchok@gmail.com
Key Words	Hepatocellular carcinoma; Hepatectomy; Portal vein ligation; Associating Liver Partition and Portal Vein Ligation in Staged Hepatectomy; Portal vein embolization
Core Tip	There are different ways to increase the resectability of hepatocellular carcinoma by increasing the volume of the future liver remnant (FLR) through hypertrophy. Portal vein embolization features the the embolization of the ipsilateral side of the portal vein which supplies the liver lobe harboring the tumor, either in an open or percutaneous manner. Sequential transarterial chemoembolization and portal vein embo-lization is a way to augment the effect of portal vein embolization and prevent tumor progression. Staged hepatectomy is mainly for liver tumors with bilobar involvement and colorectal liver metastasis and is often aided by effective adjuvant chemotherapy. Its aim is to strike a balance between complete tumor removal and preservation of the FLR. Two-staged hepatectomy with portal vein ligation is also mainly for liver tumors with bilobar involvement and colorectal liver metastasis. In the first-stage operation, tumor in the liver portion which is designated as the FLR is cleared, and portal vein ligation is performed. The liver parenchyma is transected only in the second-stage operation. Associating Liver Partition and Portal Vein Ligation in Staged Hepatectomy is used to speed up hypertrophy in the hope that the FLR will grow large enough for a safe hepatectomy before tumor progression occurs. It features right portal vein ligation and in-situ splitting of the intended transection surface down to the inferior vena cava. In the first-stage operation, the anterior approach is encouraged and the Pringle maneuver is discouraged, and the hilar plate is left untouched.
Publish Date	2015-08-29 17:10
Citation	She WH, Chok KSH. Strategies to increase the resectability of hepatocellular carcinoma. World J Hepatol 2015; 7(18): 2147-2154
URL	http://www.wjgnet.com/1948-5182/full/v7/i18/2147.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i18.2147

Full Article (PDF)	WJH-7-2147.pdf
Full Article (Word)	WJH-7-2147.doc
Manuscript File	18742-Review.docx
Answering Reviewers	18742-Answering reviewers.pdf
Audio Core Tip	18742-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18742-Conflict-of-interest statement.pdf
Copyright License Agreement	18742-Copyright assignment.pdf
Peer-review Report	18742-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18742-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18742-Scientific misconduct check.pdf
Scientific Editor Work List	18742-Scientific editor work list.pdf