Publication Name	World Journal of Gastroenterology
Manuscript ID	18830
Country	Canada

Received	2015-04-28 19:03
Peer-Review Started	2015-05-04 16:01
To Make the First Decision	2015-06-23 14:55
Return for Revision	2015-06-26 15:11
Revised	2015-07-02 00:49
Second Decision	2015-09-13 22:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-09-15 13:30
Articles in Press	2015-09-15 13:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-21 15:20
Publish the Manuscript Online	2015-11-03 17:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Colitis-associated colon cancer: Is it in your genes?
Manuscript Source	Invited Manuscript
All Author List	Lauren Van Der Kraak, Philippe Gros and Nicole Beauchemin
Funding Agency and Grant Number	Funding Agency Grant Number Cancer Research Society 19490 (to Beauchemin N and Gros P) Canadian Institute of Health Research Doctoral Award (PA-Digestive Health) to Van Der Kraak L McGill Integrated Cancer Research Training Program studentship to Van Der Kraak L
Corresponding Author	Nicole Beauchemin, PhD, Departments of Biochemistry, Medicine and Oncology and Goodman Cancer Research Centre, McGill University, McIntyre Building, Room 702A, 3655 Promenade Sir-William-Osler, Montreal, QC H3G 1Y6, Canada. nicole.beauchemin@mcgill.ca
Key Words	Colitis-associated colorectal cancer; Inflammatory bowel disease; Forward genetics; Susceptibility genes; Azoxymethane; Dextran sulfate sodium; Mouse models
Core Tip	Colitis-associated colorectal cancer (CA-CRC) is the cause of death in 10%-15% of inflammatory bowel disease (IBD) patients. Quantitative estimates of overall CA-CRC risk are highly variable and depend of the severity, duration and location of active IBD. Recently, studies have identified IBD patients with similar patterns of colonic inflammation, but that differ with respect to CA-CRC development, suggesting a role for additional non-inflammatory risk factors in CA-CRC development. In this review, we summarize the current CA-CRC literature with a strong focus on genetic pre-disposition and highlight an emerging role for mouse models in the search for CA-CRC risk alleles.
Publish Date	2015-11-03 17:31
Citation	Van Der Kraak L, Gros P, Beauchemin N. Colitis-associated colon cancer: Is it in your genes? World J Gastroenterol 2015; 21(41): 11688-11699
URL	http://www.wjgnet.com/1007-9327/full/v21/i41/11688.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i41.11688

Full Article (PDF)	WJG-21-11688.pdf
Full Article (Word)	WJG-21-11688.doc
Manuscript File	18830-Review.docx
Answering Reviewers	18830-Answering reviewers.pdf
Audio Core Tip	18830-Audio core tip.mp3
Copyright License Agreement	18830-Copyright assignment.PDF
Peer-review Report	18830-Peer-review(s).pdf
Scientific Misconduct Check	18830-Scientific misconduct check.pdf
Scientific Editor Work List	18830-Scientific editor work list.pdf