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Articles Published Processes
11/3/2015 5:30:00 PM | Browse: 1199 | Download: 1754
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Received |
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2015-04-28 19:03 |
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Peer-Review Started |
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2015-05-04 16:01 |
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To Make the First Decision |
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2015-06-23 14:55 |
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Return for Revision |
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2015-06-26 15:11 |
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Revised |
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2015-07-02 00:49 |
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Second Decision |
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2015-09-13 22:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-09-15 13:30 |
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Articles in Press |
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2015-09-15 13:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-10-21 15:20 |
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Publish the Manuscript Online |
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2015-11-03 17:31 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Colitis-associated colon cancer: Is it in your genes?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lauren Van Der Kraak, Philippe Gros and Nicole Beauchemin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Cancer Research Society |
19490 (to Beauchemin N and Gros P) |
| Canadian Institute of Health Research Doctoral Award (PA-Digestive Health) |
to Van Der Kraak L |
| McGill Integrated Cancer Research Training Program studentship |
to Van Der Kraak L |
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| Corresponding Author |
Nicole Beauchemin, PhD, Departments of Biochemistry, Medicine and Oncology and Goodman Cancer Research Centre, McGill University, McIntyre Building, Room 702A, 3655 Promenade Sir-William-Osler, Montreal, QC H3G 1Y6, Canada. nicole.beauchemin@mcgill.ca |
| Key Words |
Colitis-associated colorectal cancer; Inflammatory bowel disease; Forward genetics; Susceptibility genes; Azoxymethane; Dextran sulfate sodium; Mouse models |
| Core Tip |
Colitis-associated colorectal cancer (CA-CRC) is the cause of death in 10%-15% of inflammatory bowel disease (IBD) patients. Quantitative estimates of overall CA-CRC risk are highly variable and depend of the severity, duration and location of active IBD. Recently, studies have identified IBD patients with similar patterns of colonic inflammation, but that differ with respect to CA-CRC development, suggesting a role for additional non-inflammatory risk factors in CA-CRC development. In this review, we summarize the current CA-CRC literature with a strong focus on genetic pre-disposition and highlight an emerging role for mouse models in the search for CA-CRC risk alleles. |
| Publish Date |
2015-11-03 17:31 |
| Citation |
Van Der Kraak L, Gros P, Beauchemin N. Colitis-associated colon cancer: Is it in your genes? World J Gastroenterol 2015; 21(41): 11688-11699 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i41/11688.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i41.11688 |
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