Publication Name	World Journal of Gastroenterology
Manuscript ID	18926
Country	China

Received	2015-04-28 12:07
Peer-Review Started	2015-05-06 21:52
To Make the First Decision	2015-09-29 13:53
Return for Revision	2015-09-30 09:26
Revised	2015-10-12 15:50
Second Decision	2015-11-02 16:29
Accepted by Journal Editor-in-Chief	2015-11-04 09:09
Accepted by Executive Editor-in-Chief	2015-11-19 13:21
Articles in Press	2015-11-19 13:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-11-30 11:09
Typeset the Manuscript	2015-12-15 08:34
Publish the Manuscript Online	2015-12-31 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Topic Highlights
Article Title	Metabolic derivatives of alcohol and the molecular culprits of fibro-hepatocarcinogenesis: Allies or enemies?
Manuscript Source	Invited Manuscript
All Author List	Alex Boye, Yu-Hong Zou and Yan Yang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81374012 National Natural Science Foundation of China 81573652
Corresponding Author	Yan Yang, MD, PhD, Professor, Department of Pharmacology and Institute of Natural Medicine, Anhui Medical University, Meishan Road, Hefei 230032, Anhui Province, China. yangyan@ahmu.edu.cn
Key Words	Alcoholic hepatitis; Lipopolysaccharide; Fibro-hepatocarcinogenesis; Mitogen activated protein kinase; Transforming growth factor beta; Small mother against decapentaplegic
Core Tip	Alcoholic liver disease (ALD) leading to fibro-hepatocarcinogenesis may show a bidirectional origin within the gut-liver axis. We bring to light the subtle reprogramming of the gut epithelium, gut microbiome and hepatic cells by both metabolic derivatives and unstable chemical species secondary to chronic alcohol intake, and their concerted role in ALD. We specifically highlight the integrative role of transforming growth factor-β/Smad, which synchronizes inflammatory and fibrogenic signals within the gut-liver axis. The gut may provide a less invasive option not only for prognosis and treatment of ALD but also for future research. We suggest that therapies for ALD and fibro-hepatocarcinogenesis should focus on restoring the gut microbiome.
Publish Date	2015-12-31 13:27
Citation	Boye A, Zou YH, Yang Y. Metabolic derivatives of alcohol and the molecular culprits of fibro-hepatocarcinogenesis: Allies or enemies? World J Gastroenterol 2016; 22(1): 50-71
URL	http://www.wjgnet.com/1007-9327/full/v22/i1/50.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i1.50

Full Article (PDF)	WJG-22-50.pdf
Full Article (Word)	WJG-22-50.doc
Manuscript File	18926-Review.docx
Answering Reviewers	18926-Answering reviewers.pdf
Audio Core Tip	18926-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18926-Conflict-of-interest statement.pdf
Copyright License Agreement	18926-Copyright statement.pdf
Peer-review Report	18926-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18926-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18926-Scientific misconduct check.pdf
Scientific Editor Work List	18926-Scientific editor work list.pdf