Publication Name	World Journal of Gastroenterology
Manuscript ID	18938
Country	Taiwan

Received	2015-04-28 14:38
Peer-Review Started	2015-05-07 07:59
To Make the First Decision	2015-06-02 15:13
Return for Revision	2015-06-09 11:53
Revised	2015-06-18 14:43
Second Decision	2015-08-19 15:11
Accepted by Journal Editor-in-Chief	2015-08-21 01:25
Accepted by Company Editor-in-Chief	2015-08-31 17:52
Articles in Press	2015-08-31 17:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-16 10:55
Publish the Manuscript Online	2015-11-03 17:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Pathophysiological mechanisms of death resistance in colorectal carcinoma
Manuscript Source	Invited Manuscript
All Author List	Ching-Ying Huang and Linda Chia-Hui Yu
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Technology MOST 103-2811-B-002 -060 Ministry of Science and Technology MOST 102-2628-B-002-009-MY3 National Taiwan University NTU-CDP-104R7798
Corresponding Author	Linda Chia-Hui Yu, PhD, Associate Professor, Graduate Institute of Physiology, National Taiwan University College of Medicine, Suite 1020, 1 Jen-Ai Rd. Sec. I, Taipei 100, Taiwan. lchyu@ntu.edu.tw
Key Words	Colon cancer; Tumorigenesis; Anti-apoptosis; Chemoresistance; Anti-necroptosis; Cytoprotection
Core Tip	The mechanisms underlying anti-death cytoprotection and tumor resistance bear common pathways, and although distinguishing them would be a challenge, it would also provide an opportunity to develop advanced anti-cancer therapeutics. Auto?crine, paracrine and exogenous factors within a tumor microenvironment may instigate apoptotic and necroptotic resistance in colon cancers. The roles of cyclooxygenase-2/prostaglandin E2, growth factors, glucose, and bacterial lipopolysaccharide will be highlighted. Targeting death resistance pathways in colon cancer tissue might be a promising approach outside of anti-proliferation and anti-angiogenesis strategies for developing novel drugs to treat refractory tumors.
Publish Date	2015-11-03 17:31
Citation	Huang CY, Yu LCH. Pathophysiological mechanisms of death resistance in colorectal carcinoma. World J Gastroenterol 2015; 21(41): 11777-11792
URL	http://www.wjgnet.com/1007-9327/full/v21/i41/11777.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i41.11777

Full Article (PDF)	WJG-21-11777.pdf
Full Article (Word)	WJG-21-11777.doc
Manuscript File	18938-Review.docx
Answering Reviewers	18938-Answering reviewers.pdf
Audio Core Tip	18938-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18938-Conflict-of-interest statement.pdf
Copyright License Agreement	18938-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18938-Language certificate.pdf
Peer-review Report	18938-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18938-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18938-Scientific misconduct check.pdf
Scientific Editor Work List	18938-Scientific editor work list.pdf