Publication Name	World Journal of Gastroenterology
Manuscript ID	18963
Country	China

Received	2015-04-29 14:38
Peer-Review Started	2015-05-05 14:07
To Make the First Decision	2015-06-23 14:56
Return for Revision	2015-06-26 15:25
Revised	2015-07-15 10:55
Second Decision	2015-11-03 18:02
Accepted by Journal Editor-in-Chief	2015-11-05 18:41
Accepted by Executive Editor-in-Chief	2015-11-13 17:02
Articles in Press	2015-11-13 17:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-02 15:55
Publish the Manuscript Online	2016-01-15 14:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Emerging role of Hippo pathway in gastric and other gastrointestinal cancers
Manuscript Source	Invited Manuscript
All Author List	Wei Kang, Alfred SL Cheng, Jun Yu and Ka Fai To
Funding Agency and Grant Number	Funding Agency Grant Number General Research Fund from The Research Grants Council of Hong Kong 2140855 General Research Fund from The Research Grants Council of Hong Kong CUHK14114414 (RGC Reference) National Natural Science Foundation of China 81201591 Direct Grant for Research from The Chinese University of Hong Kong 2014.2.002
Corresponding Author	Ka Fai To, Professor, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. kfto@cuhk.edu.hk
Key Words	Hippo signaling pathway; Yes-associated protein 1; MicroRNA; Oncogenic role; Tumor suppressor
Core Tip	Hippo signaling pathway is a gradually emer-ging pathway that plays a necessary role in homeostasis of gastrointestinal tissues, whereas its deregulation frequently induces the occurrence of cancers. In gastric and other gastrointestinal cancers, the upstream com-ponents of Hippo pathway often show decreased ex-pression and their downregulation loses the inhibitory effect on yes-associated protein 1 (YAP1)/TAZ. Thus YAP1/TAZ is translocated into the nucleus and exerts oncogenic function by direct binding with TEAD tran-scription factors to activate the downstream targets transcriptionally. In this brief review, we summarize the deregulation of Hippo pathway in gastric and other gastrointestinal cancers.
Publish Date	2016-01-15 14:54
Citation	Kang W, Cheng ASL, Yu J, To KF. Emerging role of Hippo pathway in gastric and other gastrointestinal cancers. World J Gastroenterol 2016; 22(3): 1279-1288
URL	http://www.wjgnet.com/1007-9327/full/v22/i3/1279.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i3.1279

Full Article (PDF)	WJG-22-1279.pdf
Full Article (Word)	WJG-22-1279.doc
Manuscript File	18963-Review.docx
Answering Reviewers	18963-Answering reviewers.pdf
Audio Core Tip	18963-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18963-Conflict-of-interest statement.pdf
Copyright License Agreement	18963-Copyright assignment.pdf
Peer-review Report	18963-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18963-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18963-Scientific misconduct check.pdf
Scientific Editor Work List	18963-Scientific editor work list.pdf