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Articles Published Processes
1/15/2016 3:02:00 PM | Browse: 1140 | Download: 2005
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Received |
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2015-04-29 14:38 |
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Peer-Review Started |
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2015-05-05 14:07 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2015-06-26 15:25 |
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Revised |
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2015-07-15 10:55 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2015-11-03 18:02 |
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Second Decision by Editor-in-Chief |
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2015-11-05 18:41 |
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Final Decision by Editorial Office Director |
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2015-11-13 17:02 |
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Articles in Press |
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2015-11-13 17:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-12-02 15:55 |
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Publish the Manuscript Online |
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2016-01-15 14:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Emerging role of Hippo pathway in gastric and other gastrointestinal cancers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wei Kang, Alfred SL Cheng, Jun Yu and Ka Fai To |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| General Research Fund from The Research Grants Council of Hong Kong |
2140855 |
| General Research Fund from The Research Grants Council of Hong Kong |
CUHK14114414 (RGC Reference) |
| National Natural Science Foundation of China |
81201591 |
| Direct Grant for Research from The Chinese University of Hong Kong |
2014.2.002 |
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| Corresponding Author |
Ka Fai To, Professor, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. kfto@cuhk.edu.hk |
| Key Words |
Hippo signaling pathway; Yes-associated protein 1; MicroRNA; Oncogenic role; Tumor suppressor |
| Core Tip |
Hippo signaling pathway is a gradually emer-ging pathway that plays a necessary role in homeostasis of gastrointestinal tissues, whereas its deregulation frequently induces the occurrence of cancers. In gastric and other gastrointestinal cancers, the upstream com-ponents of Hippo pathway often show decreased ex-pression and their downregulation loses the inhibitory effect on yes-associated protein 1 (YAP1)/TAZ. Thus YAP1/TAZ is translocated into the nucleus and exerts oncogenic function by direct binding with TEAD tran-scription factors to activate the downstream targets transcriptionally. In this brief review, we summarize the deregulation of Hippo pathway in gastric and other gastrointestinal cancers. |
| Publish Date |
2016-01-15 14:54 |
| Citation |
Kang W, Cheng ASL, Yu J, To KF. Emerging role of Hippo pathway in gastric and other gastrointestinal cancers. World J Gastroenterol 2016; 22(3): 1279-1288
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| URL |
http://www.wjgnet.com/1007-9327/full/v22/i3/1279.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i3.1279 |
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