Publication Name	World Journal of Gastroenterology
Manuscript ID	18999
Country	Spain

Received	2015-04-30 09:26
Peer-Review Started	2015-05-06 09:23
To Make the First Decision	2015-06-02 13:40
Return for Revision	2015-06-06 18:02
Revised
Second Decision	2015-11-12 18:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-01 08:16
Articles in Press	2015-12-01 08:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-17 15:26
Publish the Manuscript Online	2016-01-06 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Minireviews
Article Title	Hepatocyte transplantation program: Lessons learned and future strategies
Manuscript Source	Invited Manuscript
All Author List	Eugenia Pareja Ibars, Miriam Cortes, Laia Tolosa, Maria José Gómez-Lechón, Slivia López, José Vicente Castell and José Mir
Funding Agency and Grant Number
Corresponding Author	Eugenia Pareja Ibars, MD, PhD, Hepatobiliary and liver Transplant Surgeon, Unidad de Cirugía Hepato-Bilio-Pancreática y Trasplante Hepático, Hospital Universitario y Politécnico La Fe de Valencia, Torre F, 5ª Planta, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain. pareja_eug@gva.es
Key Words	Hepatocyte transplantation; Hepatocyte isolation; Cell therapy; Inborn errors of metabolism; Neonatal hepatocytes; Cryopreservation
Core Tip	Our aim is to share the lessons learned over time during the establishment of the hepatocyte transplantation (HT) program at our hospital and to envisage future strategies. The hepatocyte isolation and cryopreservation procedures have been optimized and, fast and sensitive criteria for assessment of functionality of hepatocyte preparations and suitability for transplantation have been set up. Neonatal hepatocytes show high-functional quality and could improve cell therapy applicability. Our results (patients with acute liver failure and inborn metabolic diseases) indicate that HT could be a safe and efficient therapy, as long as viable and high-quality, metabolically functional human hepatocytes are available.
Publish Date	2016-01-06 16:13
Citation	Ibars EP, Cortes M, Tolosa L, Gómez-Lechón MJ, López S, Castell JV, Mir J. Hepatocyte transplantation program: Lessons learned and future strategies. World J Gastroenterol 2016; 22(2): 874-886
URL	http://www.wjgnet.com/1007-9327/full/v22/i2/874.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i2.874

Full Article (PDF)	WJG-22-874.pdf
Full Article (Word)	WJG-22-874.doc
Manuscript File	18999-Review.docx
Answering Reviewers	18999-Answering reviewers.pdf
Audio Core Tip	18999-Audio core tip.m4a
Copyright License Agreement	18999-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18999-Language certificate.pdf
Peer-review Report	18999-Peer-review(s).pdf
Scientific Misconduct Check	18999-Scientific misconduct check.pdf
Scientific Editor Work List	18999-Scientific editor work list.pdf