Publication Name	World Journal of Gastroenterology
Manuscript ID	19121
Country	Italy

Received	2015-04-29 09:42
Peer-Review Started	2015-05-07 19:46
To Make the First Decision	2015-07-20 14:40
Return for Revision	2015-07-24 14:18
Revised	2015-08-13 20:25
Second Decision	2015-10-16 13:11
Accepted by Journal Editor-in-Chief	2015-10-16 15:28
Accepted by Executive Editor-in-Chief	2015-10-26 17:43
Articles in Press	2015-10-26 17:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-30 15:12
Publish the Manuscript Online	2015-11-18 12:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Genetics of inflammatory bowel disease from multifactorial to monogenic forms
Manuscript Source	Invited Manuscript
All Author List	Anna Monica Bianco, Martina Girardelli and Alberto Tommasini
Funding Agency and Grant Number	Funding Agency Grant Number grants from the Institute for Maternal and Child Health IRCCS “Burlo Garofolo”, Italy (RC 22/2012) RC 22/2012
Corresponding Author	Anna Monica Bianco, PhD, Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”, Via dell’Istria, 65/1, 34137 Trieste, Italy. annamonicarosaria.bianco@burlo.trieste.it
Key Words	Inflammatory bowel disease; Primary immunodeficiency disease; Early onset; Next gene­ration sequencing; Genome wide association studies
Core Tip	Genetic investigation is of fundamental importance describing inflammatory bowel disease (IBD) as a complex disease, as well as in identifying the monogenic disorders that may present with IBD-like features. Using third-generation technology should be leveraged to accelerate the screening and allow the identification of the most rare monogenic defects. Furthermore, the study of genetic variants in monogenic and in sporadic IBD could help unraveling the complex interplay between defective and com-pensatory immune responses, opening the way to the identification of new targets for therapy.
Publish Date	2015-11-18 12:39
Citation	Bianco AM, Girardelli M, Tommasini A. Genetics of inflam­matory bowel disease from multifactorial to monogenic forms. World J Gastroenterol 2015; 21(43): 12296-12310
URL	http://www.wjgnet.com/1007-9327/full/v21/i43/12296.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i43.12296

Full Article (PDF)	WJG-21-12296.pdf
Full Article (Word)	WJG-21-12296.doc
Manuscript File	19121-Review.docx
Answering Reviewers	19121-Answering reviewers.pdf
Audio Core Tip	19121-Audio core tip.mp3
Copyright License Agreement	19121-Copyright assignment.pdf
Peer-review Report	19121-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19121-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19121-Scientific misconduct check.pdf
Scientific Editor Work List	19121-Scientific editor work list.pdf