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Articles Published Processes
12/8/2015 9:18:00 AM | Browse: 982 | Download: 1677
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Received |
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2015-05-03 12:08 |
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Peer-Review Started |
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2015-05-08 16:54 |
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To Make the First Decision |
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2015-07-17 16:35 |
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Return for Revision |
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2015-07-22 17:20 |
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Revised |
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Second Decision |
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2015-10-13 08:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-10-27 17:50 |
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Articles in Press |
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2015-10-27 17:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-11-24 10:07 |
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Publish the Manuscript Online |
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2015-12-08 09:18 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Probable case of drug reaction with eosinophilia and systemic symptom syndrome due to combination therapy with daclatasvir and asunaprevir
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Takayoshi Suga, Ken Sato, Yuichi Yamazaki, Tatsuya Ohyama, Norio Horiguchi, Satoru Kakizaki, Motoyasu Kusano and Masanobu Yamada |
| Funding Agency and Grant Number |
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| Corresponding Author |
Ken Sato, MD, PhD, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. satoken@gunma-u.ac.jp |
| Key Words |
Hepatitis C; Daclatasvir; Renal dysfunction; Asunaprevir; Hepatic reserve deterioration |
| Core Tip |
Oral combination therapy with daclatasvir and asunaprevir for chronic hepatitis C demonstrates a relatively favorable safety profile. Although the incidence of hyperbilirubinemia, hypoalbuminemia, and a decreased prothrombin activity have been reported, as well as renal damage, concomitant deterioration of hepatic reserve and renal function without transaminase elevations have not been reported. We observed probable drug reaction with eosinophilia and systemic symptom syndrome, including concomitant deterioration of hepatic reserve and renal function due to the combination therapy, regardless of normalized transaminase levels. Thus, our case highlights the importance of paying attention not only to transaminase levels but also to the allergic symptoms associated with organ involvement during combination therapy. |
| Publish Date |
2015-12-08 09:18 |
| Citation |
Suga T, Sato K, Yamazaki Y, Ohyama T, Horiguchi N, Kakizaki S, Kusano M, Yamada M. Probable case of drug reaction with eosinophilia and systemic symptom syndrome due to combination therapy with daclatasvir and asunaprevir. World J Clin Cases 2015; 3(12): 1005-1010 |
| URL |
http://www.wjgnet.com/2307-8960/full/v3/i12/1005.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v3.i12.1005 |
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