Publication Name	World Journal of Gastroenterology
Manuscript ID	19447
Country	Japan

Received	2015-05-08 15:04
Peer-Review Started	2015-05-11 21:21
To Make the First Decision	2015-07-13 15:18
Return for Revision	2015-07-17 16:51
Revised	2015-08-08 00:00
Second Decision	2015-09-13 22:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-09-15 13:43
Articles in Press	2015-09-15 13:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-16 15:31
Publish the Manuscript Online	2015-11-03 17:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Do vasopressin V2 receptor antagonists benefit cirrhotics with refractory ascites?
Manuscript Source	Invited Manuscript
All Author List	Hiroshi Fukui
Funding Agency and Grant Number
Corresponding Author	Hiroshi Fukui, MD, PhD, Professor emeritus, Department of Gastroenterology, Endocrinology and Metabolism, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan. hfukui@naramed-u.ac.jp
Key Words	Liver cirrhosis; Ascites; Hyponatremia; Pathophysiology; V2 receptor antagonist
Core Tip	Dilutional hyponatremia is a frequent complication with high morbidity and mortality in advanced liver cirrhosis with ascites. It is attributable to disturbed water excretion related to enhanced vasopressin activity on the background of underfilling state in the splanchnic arterial circulation. V2 receptor antagonist is theoretically promising for the future treatment of hyponatremia and ascites. The present review aimed to summarize the pathophysiological backgrounds of ascites and hyponatremia and to introduce major results of all controlled trials. Although there existed several unsolved problems and controversies on the topic, discussions from the basic standpoints may light up the dark road.
Publish Date	2015-11-03 17:31
Citation	Fukui H. Do vasopressin V2 receptor antagonists benefit cirrhotics with refractory ascites? World J Gastroenterol 2015; 21(41): 11584-11596
URL	http://www.wjgnet.com/1007-9327/full/v21/i41/11584.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i41.11584

Full Article (PDF)	WJG-21-11584.pdf
Full Article (Word)	WJG-21-11584.doc
Manuscript File	19447-Review.docx
Answering Reviewers	19447-Answering reviewers.pdf
Audio Core Tip	19447-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19447-Conflict-of-interest statement.pdf
Copyright License Agreement	19447-Copyright assignment.pdf
Peer-review Report	19447-Peer-review(s).pdf
Scientific Misconduct Check	19447-Scientific misconduct check.pdf
Scientific Editor Work List	19447-Scientific editor work list.pdf