Publication Name	World Journal of Gastroenterology
Manuscript ID	19463
Country	Latvia

Received	2015-05-09 13:33
Peer-Review Started	2015-05-11 18:19
First Decision by Editorial Office Director
Return for Revision	2015-06-26 19:16
Revised	2015-07-08 23:38
Publication Fee Transferred
Second Decision by Editor	2015-09-28 16:10
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-09-30 10:19
Articles in Press	2015-09-30 10:19
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-09 20:07
Publish the Manuscript Online	2015-11-03 17:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Emerging blood-based biomarkers for detection of gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Zane Kalniņa, Irēna Meistere, Ilze Kikuste, Ivars Tolmanis, Pawel Zayakin and Aija Linē
Funding Agency and Grant Number	Funding Agency Grant Number ERDF project 2013/0052/2DP/2.1.1.1.0/13APIA/VIAA/019
Corresponding Author	Aija Linē, PhD, Latvian Biomedical Research and Study Centre, Cancer Biomarker Group, Ratsupites Str 1, k-1, LV-1067, Riga, 1067 LV, Latvia. aija@biomed.lu.lv
Key Words	Gastric cancer; Biomarker; Liquid biopsy; Cell-free DNA; Cell-free RNA; Extracellular vesicles; Autoantibodies; Proteomics
Core Tip	The identification of blood-based biomarkers that could reliably detect the presence of early-stage gastric cancer or provide means to monitor the tumor dynamics is an unmet clinical need. Recently, considerable effort has been devoted to discovering various types of cancer-associated molecules in the blood of gastric cancer patients, and this has resulted in establishing biomarker models with remarkably high sensitivity and specificity. However, a validation in large-scale studies and a head-to-head comparison of the biomarker models and technologies are required before these biomarkers can be used in routine clinical practice.
Publish Date	2015-11-03 17:31
Citation	Kalniņa Z, Meistere I, Kikuste I, Tolmanis I, Zayakin P, Linē A. Emerging blood-based biomarkers for detection of gastric cancer. World J Gastroenterol 2015; 21(41): 11636-11653
URL	http://www.wjgnet.com/1007-9327/full/v21/i41/11636.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i41.11636

Full Article (PDF)	WJG-21-11636.pdf
Full Article (Word)	WJG-21-11636.doc
Manuscript File	19463-Review.docx
Answering Reviewers	19463-Answering reviewers.pdf
Audio Core Tip	19463-Audio core tip.wav
Conflict-of-Interest Disclosure Form	19463-Conflict-of-interest statement.pdf
Copyright License Agreement	19463-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19463-Language certificate.pdf
Peer-review Report	19463-Peer-review(s).pdf
Scientific Misconduct Check	19463-Scientific misconduct check.pdf
Scientific Editor Work List	19463-Scientific editor work list.pdf