Publication Name	World Journal of Gastroenterology
Manuscript ID	19472
Country	United States

Received	2015-05-09 13:19
Peer-Review Started	2015-05-12 15:38
To Make the First Decision	2015-06-02 15:09
Return for Revision	2015-06-04 15:09
Revised	2015-06-13 09:35
Second Decision	2015-07-07 22:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-07-08 17:53
Articles in Press	2015-07-08 17:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-07 11:24
Publish the Manuscript Online	2015-08-20 13:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Genetics & Heredity
Manuscript Type	Topic Highlights
Article Title	Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer
Manuscript Source	Invited Manuscript
All Author List	John M Carethers and Elena M Stoffel
Funding Agency and Grant Number	Funding Agency Grant Number United States Public Health Service DK067287 United States Public Health Service CA162147 A. Alfred Taubman Medical Research Institute of the University of Michigan
Corresponding Author	John M Carethers, MD, Division of Gastroenterology, Department of Internal Medicine, University of Michigan, 500 S. State Street, Ann Arbor, MI 48109-5368, United States. jcarethe@umich.edu
Key Words	Hereditary non-polyposis colorectal cancer; Lynch syndrome; Lynch-like syndrome; Familial colorectal cancer; DNA mismatch repair; microsatellite instability; Familial colorectal cancer type X; Constitutional mismatch repair deficiency syndrome; Hereditary colorectal cancer
Core Tip	Clinical criteria and phenotypic presentation of patients and families with hereditary non-polyposis colorectal cancer (HNPCC) do not adequately differentiate the several genetic diseases now classified under HNPCC. Tumor analysis for microsatellite instability (MSI) can dichotimize for the clinician conditions with MSI or without MSI, allowing a focused differential diagnosis. Individual or panel germline genetic testing can further differentiate HNPCC into its genetically defined syndromes or its phenocopies.
Publish Date	2015-08-20 13:37
Citation	Carethers JM, Stoffel EM. Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer. World J Gastroenterol 2015; 21(31): 9253-9261
URL	http://www.wjgnet.com/1007-9327/full/v21/i31/9253.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i31.9253

Full Article (PDF)	WJG-21-9253.pdf
Full Article (Word)	WJG-21-9253.doc
Manuscript File	19472-Review.docx
Answering Reviewers	19472-Answering reviewers.pdf
Audio Core Tip	19472-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	19472-Conflict-of-interest statement.pdf
Copyright License Agreement	19472-Copyright assignment.pdf
Peer-review Report	19472-Peer-review(s).pdf
Scientific Misconduct Check	19472-Scientific misconduct check.pdf
Scientific Editor Work List	19472-Scientific editor work list.pdf