| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Marlein Miranda Cona, Ye-Wei Liu, Antoine Hubert, Ting Yin, Yuan-Bo Feng, Peter de Witte, Etienne Waelkens, Yan-Sheng Jiang, Jian Zhang, Stefaan Mulier, Qian Xia, Gang Huang, Raymond Oyen and Yi-Cheng Ni |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Dr. Yi-Cheng Ni, MD, PhD, Professor, Department of Imaging and Pathology, Faculty of Medicine, Biomedical Sciences Group, University Hospitals, KU Leuven, Herestraat 49, B-3000 Leuven,
Belgium. yicheng.ni@med.kuleuven.be |
| Key Words |
Differential detection; Fluorescence; Human gallstones; Hypericin; Rat model of cholelithiasis |
| Core Tip |
Cholelithiasis refers to cholesterol, mixed and pigment gallstones in the gallbladder. Although the current diagnostic methods may detect their presence in the biliary system, none of them may offer an in situ differential diagnosis of gallstones regarding their chemical composition. Hypericin is a fluorophore plant pigment tending to bind membrane lipids and is excreted via bile. Because cholesterol is likely the target that hypericin binds, hypericin could become a potential optical imaging agent for differential fluorescent detection of gallstones. Such imaging procedures would allow identifying the origin, composition and formation of gallstones in patients and permit adopting strategies to minimize cholelithiasis recurrence.
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| Publish Date |
2016-07-29 20:32 |
| Citation |
Miranda Cona M, Liu YW, Hubert A, Yin T, Feng YB, de Witte P, Waelkens E, Jiang YS, Zhang J, Mulier S, Xia Q, Huang G, Oyen R, Ni YC. Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent. World J Gastroenterol 2016; 22(29): 6690-6705 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i29/6690.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i29.6690 |
