| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
CD24 genetic variants contribute to overall survival in patients with gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Fang Jia, Li-Zhong Wang, Xue-Yuan Cao, Chuan Wang, Dong-Hui Cao, Xing Wu, Li-Li You, Mei-Shan Jin, Yin-Ping Wang, Bao-Sen Zhou and Jing Jiang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81373084 |
| National Natural Science Foundation of China |
81273065 |
| Norman Bethune Program of Jilin University |
2013025 |
| Youth Fund of the First Hospital of Jilin University |
JDYY42013014 |
|
| Corresponding Author |
Jing Jiang, MD, PhD, Division of Clinical Epidemiology, First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, Jilin Province,
China. jiangjing19702000@jlu.edu.cn |
| Key Words |
Gastric cancer; CD24; Single nucleotide polymorphisms; Gastric atrophy; Overall survival |
| Core Tip |
We evaluated the role of three genetic variants of CD24 in gastric cancer (GC) risk and prognosis using 679 GC cases and 976 controls. We observed that GC cases with the A/A genotype of P-534 (which lies in the CD24 promoter) had a significantly shorter survival (HR = 1.38) especially among patients who lived longer than 2.5 years (HR = 7.55) after adjusting for age, sex, histological type, tumor differentiation, clinical stage and post-operational chemotherapy. Our study provides the first evidence that P-534 site in CD24 may serve as a prognostic marker for gastric cancer.
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| Publish Date |
2016-01-31 11:48 |
| Citation |
Jia ZF, Wang LZ, Cao XY, Wang C, Cao DH, Wu X, You LL, Jin MS, Wang YP, Zhou BS, Jiang J. CD24 genetic variants contribute to overall survival in patients with gastric cancer. World J Gastroenterol 2016; 22(7): 2373-2382 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i7/2373.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i7.2373 |
