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10/23/2015 3:58:00 PM | Browse: 572 | Download: 748
Publication Name World Journal of Gastroenterology
Manuscript ID 19526
Country/Territory United States
2015-05-11 16:34
Peer-Review Started
2015-05-14 14:28
To Make the First Decision
2015-06-02 14:54
Return for Revision
2015-06-06 18:30
2015-06-26 20:50
Second Decision
2015-09-28 16:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-09-30 10:20
Articles in Press
2015-09-30 10:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-13 17:13
Publish the Manuscript Online
2015-10-23 15:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier
Manuscript Source Invited Manuscript
All Author List Tyler J Caron, Kathleen E Scott, James G Fox and Susan J Hagen
Funding Agency and Grant Number
Funding Agency Grant Number
Department of Surgery funds, BIDMC and NIH P30 DK034854 (SJH)
Department of Surgery funds, BIDMC and NIH R01 CA093405
Department of Surgery funds, BIDMC and NIH P30 ES002109
Department of Surgery funds, BIDMC and NIH R01 OD011141
Department of Surgery funds, BIDMC and NIH No. P01 CA028842 (JGF)
NIH T32 OD0109978 (JGF, to Dr. Caron and Dr. Scott)
Corresponding author Susan J Hagen, PhD, Department of Surgery, Beth Israel Deaconess Medical Center, E/RW-871, 330 Brookline Avenue, Boston, MA 01125, United States. shagen@bidmc.harvard.edu
Keywords Helicobacter pylori; Tight junction; Claudins; Paracellular permeability; Stomach; Cytotoxin-associated gene A; Vacuolating cytotoxin; Lipopolysaccharide; Urease; Ammonia
Core Tip Tight junction dysfunction is a risk factor for cancer development during Helicobacter pylori (H. pylori) infection. The recent identification of numerous barrier-forming claudins has greatly improved our understanding of properties that regulate selective permeation across the tight junction in general, but little is known about the role of claudins in the stomach, or in H. pylori infection. In this article, we review the current state of knowledge on stomach tight junction composition and organization, discuss the details of claudin expression in various species and in cultured gastric cells, and discuss the implications of tight junction dysregulation in gastric cancer pathogenesis.
Publish Date 2015-10-23 15:45
Citation Caron TJ, Scott KE, Fox JG, Hagen SJ. Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier. World J Gastroenterol 2015; 21(40): 11411-11427
Url http://www.wjgnet.com/1007-9327/full/v21/i40/11411.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i40.11411
Full Article (PDF) WJG-21-11411.pdf
Full Article (Word) WJG-21-11411.doc
Manuscript File 19526-Review.docx
Answering Reviewers 19526-Answering reviewers.pdf
Audio Core Tip 19526-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 19526-Conflict of interest statement.pdf
Copyright License Agreement 19526-Copyright assignment.pdf
Peer-review Report 19526-Peer-review(s).pdf
Scientific Misconduct Check 19526-Scientific misconduct check.pdf
Scientific Editor Work List 19526-Scientific editor work list.pdf