Publication Name	World Journal of Clinical Oncology
Manuscript ID	19749
Country	Japan

Received	2015-05-20 09:16
Peer-Review Started	2015-05-20 21:40
To Make the First Decision	2015-08-16 16:54
Return for Revision	2015-08-19 19:53
Revised	2015-08-25 13:36
Second Decision	2015-10-14 08:42
Accepted by Journal Editor-in-Chief	2015-10-15 00:27
Accepted by Executive Editor-in-Chief	2015-10-27 18:26
Articles in Press	2015-10-27 18:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-28 19:00
Publish the Manuscript Online	2015-12-09 18:37

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Editorial
Article Title	Tumor biology in estrogen receptor-positive, human epidermal growth factor receptor type 2-negative breast cancer: Mind the menopausal status
Manuscript Source	Invited Manuscript
All Author List	Hiroko Yamashita
Funding Agency and Grant Number
Corresponding Author	Hiroko Yamashita, MD, PhD, Breast Surgery, Hokkaido University Hospital, Kita 14, Nishi 5, Kita-ku, Sapporo 060-8648, Japan. hirokoy@huhp.hokudai.ac.jp
Key Words	Breast cancer; Progesterone receptor; Estrogen receptor; Ki67; Menopausal status
Core Tip	Progesterone receptor (PgR) is one of the estrogen-responsive genes, and it has been reported that plasma estradiol levels are related to expression levels of estrogen-responsive genes including PGR in estrogen receptor (ER)-positive breast cancer. In this article, biological differences, especially differences in expression of PgR and Ki67 in ER-positive breast cancer between pre- and postmenopausal women are discussed. Clinical roles of PgR and Ki67 in ER-positive breast cancer differ between pre- and postmenopausal women. We suggest that the mechanisms of develo-pment and estrogen-dependent growth of ER-positive breast cancer might differ according to menopausal status.
Publish Date	2015-12-09 18:37
Citation	Yamashita H. Tumor biology in estrogen receptor-positive, human epidermal growth factor receptor type 2-negative breast cancer: Mind the menopausal status. World J Clin Oncol 2015; 6(6): 220-224
URL	http://www.wjgnet.com/2218-4333/full/v6/i6/220.htm
DOI	http://dx.doi.org/10.5306/wjco.v6.i6.220

Full Article (PDF)	WJCO-6-220.pdf
Full Article (Word)	WJCO-6-220.doc
Manuscript File	19749-Review.docx
Answering Reviewers	19749-Answering revieweres.pdf
Audio Core Tip	19749-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19749-Conflict-of-interest statement.pdf
Copyright License Agreement	19749-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	19749-Language certificate.pdf
Peer-review Report	19749-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19749-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19749-Scientific misconduct check.pdf
Scientific Editor Work List	19749-Scientific editor work list.pdf