Publication Name	World Journal of Orthopedics
Manuscript ID	19800
Country	Italy

Received	2015-05-21 16:21
Peer-Review Started	2015-05-25 08:07
To Make the First Decision	2015-07-27 15:46
Return for Revision	2015-08-04 09:58
Revised	2015-08-11 21:02
Second Decision	2015-10-13 08:38
Accepted by Journal Editor-in-Chief	2015-10-14 23:03
Accepted by Executive Editor-in-Chief	2015-10-27 18:16
Articles in Press	2015-10-27 18:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-01 11:15
Publish the Manuscript Online	2015-12-17 21:04

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Systematic Reviews
Article Title	Use of chondral fragments for one stage cartilage repair: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Davide Edoardo Bonasia, Antongiulio Marmotti, Federica Rosso, Gianluca Collo and Roberto Rossi
Funding Agency and Grant Number
Corresponding Author	Davide Edoardo Bonasia, MD, Department of Orthopaedics and Traumatology, University of Torino, AO Mauriziano “Umberto I” Hospital, Via Lamarmora 26, 10128 Torino, Italy. davidebonasia@virgilio.it
Key Words	Cartilage; Juvenile; Chondral fragments; Adult; Particulated cartilage
Core Tip	In this systematic review regarding Cartilage Autograft Implantation System (CAIS) and Particulated Juvenile Allograft Cartilage (PJAC), basic science and clinical articles with more than 10 patients treated and more than 6 mo of follow-up were included. A total of 17 articles were available for the present review. Good basic science evidence in vitro and in vivo was described to support the concept of CAIS. Only one level Ⅱ paper reported the clinical results of the CAIS technique. On the other hand, little basic science evidence and 4 preliminary clinical trials are available regarding the PJAC technique. CAIS and PJAC represent promising single step solutions for cartilage restoration with hyaline-like repair. However, many controversies still exist regarding both techniques, including the indications (age of the patients, size of the lesion, and involvement of the subchondral bone).
Publish Date	2015-12-17 21:04
Citation	Bonasia DE, Marmotti A, Rosso F, Collo G, Rossi R. Use of chondral fragments for one stage cartilage repair: A systematic review. World J Orthop 2015; 6(11): 1006-1011
URL	http://www.wjgnet.com/2218-5836/full/v6/i11/1006.htm
DOI	http://dx.doi.org/10.5312/wjo.v6.i11.1006

Full Article (PDF)	WJO-6-1006.pdf
Full Article (Word)	WJO-6-1006.doc
Manuscript File	19800-Review.docx
Answering Reviewers	19800-Answering reviewers.pdf
Audio Core Tip	19800-Audio core tip.wav
Biostatistics Review Certificate	19800-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	19800-Conflict-of-interest statement.pdf
Copyright License Agreement	19800-Copyright assignment.pdf
Peer-review Report	19800-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19800-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19800-Scientific misconduct check.pdf
Scientific Editor Work List	19800-Scientific editor work list.pdf