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1/20/2016 5:04:00 PM | Browse: 680 | Download: 634
Publication Name World Journal of Gastroenterology
Manuscript ID 19821
Country/Territory United States
Received
2015-05-22 16:32
Peer-Review Started
2015-05-23 15:14
To Make the First Decision
2015-09-29 13:52
Return for Revision
2015-09-30 09:28
Revised
2015-10-29 20:52
Second Decision
2015-11-10 08:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-11-19 13:25
Articles in Press
2015-11-19 13:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-06 18:05
Publish the Manuscript Online
2016-01-20 16:55
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Frontier
Article Title Molecular genetics and targeted therapeutics in biliary tract carcinoma
Manuscript Source Invited Manuscript
All Author List Eric I Marks and Nelson S Yee
Funding Agency and Grant Number
Corresponding author Nelson S Yee, MD, PhD, Program of Experimental Therapeutics, Penn State Hershey Cancer Institute, 500 University Drive, Hershey, PA 17033-0850, United State. nyee@hmc.psu.edu
Keywords Biliary tract carcinoma; Cholangiocarcinoma; Gallbladder carcinoma; Molecular genetics; Personalized treatment; Precision therapy; Targeted therapy
Core Tip For patients with cholangiocarcinoma and gallbladder carcinoma, targeted therapeutics provide new opportunity of treatment that is potentially less toxic and more effective. These target-specific monoclonal antibodies and small molecule inhibitors are directed against the signaling pathways that drive the progression of biliary tract cancers. This article provides an updated review of the molecular pathogenesis of these malignant neoplasms as the framework for describing the mechanisms by which targeted agents work. The preclinical and clinical data from investigation of targeted therapeutics in biliary tract cancer are discussed.
Publish Date 2016-01-20 16:55
Citation Marks EI, Yee NS. Molecular genetics and targeted therapeutics in biliary tract carcinoma. World J Gastroenterol 2016; 22(4): 1335-1347
Url http://www.wjgnet.com/1007-9327/full/v22/i4/1335.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i4.1335
Full Article (PDF) WJG-22-1335.pdf
Full Article (Word) WJG-22-1335.doc
Manuscript File 19821-Review.docx
Answering Reviewers 19821-Answering reviewers.pdf
Audio Core Tip 19821-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 19821-Conflict-of-interest statement.pdf
Copyright License Agreement 19821-Copyright assignment.pdf
Peer-review Report 19821-Peer-review(s).pdf
Scientific Misconduct Check 19821-Scientific misconduct check.pdf
Scientific Editor Work List 19821-Scientific editor work list.pdf